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Surveillance investigations after high-dose therapy with stem cell rescue for recurrent follicular lymphoma have no impact on management

Surveillance investigations after high-dose therapy with stem cell rescue for recurrent follicular lymphoma have no impact on management
Surveillance investigations after high-dose therapy with stem cell rescue for recurrent follicular lymphoma have no impact on management
Background: The impact of active surveillance, comprising an annual CT scan and bone marrow biopsies, in the follow-up of patients after high-dose therapy (HDT) with autologous stem cell rescue for recurrent follicular lymphoma was analyzed.

Design and Methods: Seventy-one of 99 patients who received HDT commenced on the surveillance program. Response duration, time-to-next-treatment and overall survival (OS) were compared, according to whether disease progression had been diagnosed on the basis of surveillance investigations or clinical grounds.

Results: After a median follow-up of 16 years, progression was documented by surveillance in 16 patients and clinically in 18, the median response duration being 2.4 and 2.3 years, respectively (p=NS). Ten patients with a clinical relapse started treatment immediately contrasting with one patient who had a surveillance relapse. Five patients with relapses on surveillance investigations have not required treatment after a median follow-up of 18 years, whereas all but 2 patients with a clinical relapse have been treated. The median time-to-next-treatment was 7 years for patients with a surveillance relapse and 4 years for those with a clinical relapse (p=0.03). OS was not significantly different.

Conclusions: Surveillance investigations have no impact on management and do not improve the outcome of this population.
0390-6078
1130-1135
Gerlinger, Marco
dd527a35-4c64-4d27-ac7b-c0fac9a58ba7
Rohatiner, Ama Z.S.
cbad88d3-2231-4d20-a236-9da6d127e204
Matthews, Janet
baa9d6ab-0e42-4ac6-8a95-48ce92acc38b
Davies, Andrew
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Lister, T. Andrew
6b42a014-ee50-4017-bbb8-16aa71b74018
Montoto, Silvia
890fe3f0-1910-49b4-97d4-993e2701052f
Gerlinger, Marco
dd527a35-4c64-4d27-ac7b-c0fac9a58ba7
Rohatiner, Ama Z.S.
cbad88d3-2231-4d20-a236-9da6d127e204
Matthews, Janet
baa9d6ab-0e42-4ac6-8a95-48ce92acc38b
Davies, Andrew
0fe6a40a-10d1-4ade-a7e6-d1dceb2470af
Lister, T. Andrew
6b42a014-ee50-4017-bbb8-16aa71b74018
Montoto, Silvia
890fe3f0-1910-49b4-97d4-993e2701052f

Gerlinger, Marco, Rohatiner, Ama Z.S., Matthews, Janet, Davies, Andrew, Lister, T. Andrew and Montoto, Silvia (2010) Surveillance investigations after high-dose therapy with stem cell rescue for recurrent follicular lymphoma have no impact on management. Haematologica, 95 (7), 1130-1135. (doi:10.3324/haematol.2009.020115).

Record type: Article

Abstract

Background: The impact of active surveillance, comprising an annual CT scan and bone marrow biopsies, in the follow-up of patients after high-dose therapy (HDT) with autologous stem cell rescue for recurrent follicular lymphoma was analyzed.

Design and Methods: Seventy-one of 99 patients who received HDT commenced on the surveillance program. Response duration, time-to-next-treatment and overall survival (OS) were compared, according to whether disease progression had been diagnosed on the basis of surveillance investigations or clinical grounds.

Results: After a median follow-up of 16 years, progression was documented by surveillance in 16 patients and clinically in 18, the median response duration being 2.4 and 2.3 years, respectively (p=NS). Ten patients with a clinical relapse started treatment immediately contrasting with one patient who had a surveillance relapse. Five patients with relapses on surveillance investigations have not required treatment after a median follow-up of 18 years, whereas all but 2 patients with a clinical relapse have been treated. The median time-to-next-treatment was 7 years for patients with a surveillance relapse and 4 years for those with a clinical relapse (p=0.03). OS was not significantly different.

Conclusions: Surveillance investigations have no impact on management and do not improve the outcome of this population.

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More information

e-pub ahead of print date: 27 January 2010
Published date: July 2010

Identifiers

Local EPrints ID: 73244
URI: http://eprints.soton.ac.uk/id/eprint/73244
ISSN: 0390-6078
PURE UUID: a58c3331-b58c-4f5a-9e50-5e7311aae864
ORCID for Andrew Davies: ORCID iD orcid.org/0000-0002-7517-6938

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Date deposited: 03 Mar 2010
Last modified: 14 Mar 2024 02:54

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Contributors

Author: Marco Gerlinger
Author: Ama Z.S. Rohatiner
Author: Janet Matthews
Author: Andrew Davies ORCID iD
Author: T. Andrew Lister
Author: Silvia Montoto

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