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Versatile biocompatible polymer hydrogels: scaffolds for cell growth

Versatile biocompatible polymer hydrogels: scaffolds for cell growth
Versatile biocompatible polymer hydrogels: scaffolds for cell growth
A three-dimensional, biocompatible hydrogel (see picture) was generated by combining two cationic polymers, chitosan and poly(ethylenimine). The hydrogels were stable under cell-culture conditions and facilitated cell proliferation, yet prevented dedifferentiation of primary human skeletal cells into fibroblasts. A variety of materials such as DNA, proteins, and peptides can be stably incorporated into the gel network
cells, dna, hydrogels, polymers, scaffolds
1433-7851
978-982
Khan, Ferdous
e42bd53d-7669-4a7e-bb33-f17b70660c2b
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
Khan, Ferdous
e42bd53d-7669-4a7e-bb33-f17b70660c2b
Tare, Rahul S.
587c9db4-e409-4e7c-a02a-677547ab724a
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900

Khan, Ferdous, Tare, Rahul S., Oreffo, Richard O.C. and Bradley, Mark (2009) Versatile biocompatible polymer hydrogels: scaffolds for cell growth. Angewandte Chemie International Edition, 48 (5), 978-982. (doi:10.1002/anie.200804096). (PMID:19115339)

Record type: Article

Abstract

A three-dimensional, biocompatible hydrogel (see picture) was generated by combining two cationic polymers, chitosan and poly(ethylenimine). The hydrogels were stable under cell-culture conditions and facilitated cell proliferation, yet prevented dedifferentiation of primary human skeletal cells into fibroblasts. A variety of materials such as DNA, proteins, and peptides can be stably incorporated into the gel network

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More information

e-pub ahead of print date: 29 December 2008
Published date: 19 January 2009
Keywords: cells, dna, hydrogels, polymers, scaffolds

Identifiers

Local EPrints ID: 73271
URI: http://eprints.soton.ac.uk/id/eprint/73271
ISSN: 1433-7851
PURE UUID: 2a6d7931-2173-42e8-a827-93ddfd2938d9
ORCID for Rahul S. Tare: ORCID iD orcid.org/0000-0001-8274-8837
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

Catalogue record

Date deposited: 04 Mar 2010
Last modified: 14 Mar 2024 02:49

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Contributors

Author: Ferdous Khan
Author: Rahul S. Tare ORCID iD
Author: Mark Bradley

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