Cohort profile: The Hertfordshire Ageing Study (HAS)
Cohort profile: The Hertfordshire Ageing Study (HAS)
We have previously described the discovery of a unique set of infant records collected in Hertfordshire between 1911 and 1948.1 The historical data for births between 1911 and 1930 were linked to the NHS central register and showed that small size at birth and during infancy was associated with increased risk of cardiovascular mortality in men and women.2,3 These were the first studies based on individual data to suggest that adverse environmental influences acting in utero and during infancy might increase the risk of cardiovascular disease mortality in later life.
Detailed physiological investigations of surviving men and women born in Hertfordshire between 1920 and 1930 and still living there in the early 1990s were subsequently conducted and allowed investigation of morbidity. Studies based on men and women resident in East Hertfordshire demonstrated that small size at birth and during infancy was associated with increased risk of developing coronary heart disease
36-43
Syddall, H.E.
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Simmonds, S.J.
2214e6b5-868a-4dae-8491-fca5d5a8ecb8
Martin, H.J.
34384528-4b85-41c3-95dc-16ade10aaf44
Watson, C.
22fa592a-1fe1-4660-9cdc-825381ce151e
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
February 2010
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Simmonds, S.J.
2214e6b5-868a-4dae-8491-fca5d5a8ecb8
Martin, H.J.
34384528-4b85-41c3-95dc-16ade10aaf44
Watson, C.
22fa592a-1fe1-4660-9cdc-825381ce151e
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Syddall, H.E., Simmonds, S.J., Martin, H.J., Watson, C., Dennison, E.M., Cooper, C. and Sayer, A.A.
(2010)
Cohort profile: The Hertfordshire Ageing Study (HAS).
International Journal of Epidemiology, 39 (1), .
(doi:10.1093/ije/dyn275).
Abstract
We have previously described the discovery of a unique set of infant records collected in Hertfordshire between 1911 and 1948.1 The historical data for births between 1911 and 1930 were linked to the NHS central register and showed that small size at birth and during infancy was associated with increased risk of cardiovascular mortality in men and women.2,3 These were the first studies based on individual data to suggest that adverse environmental influences acting in utero and during infancy might increase the risk of cardiovascular disease mortality in later life.
Detailed physiological investigations of surviving men and women born in Hertfordshire between 1920 and 1930 and still living there in the early 1990s were subsequently conducted and allowed investigation of morbidity. Studies based on men and women resident in East Hertfordshire demonstrated that small size at birth and during infancy was associated with increased risk of developing coronary heart disease
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Published date: February 2010
Organisations:
Dev Origins of Health & Disease
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Local EPrints ID: 73358
URI: http://eprints.soton.ac.uk/id/eprint/73358
ISSN: 0300-5771
PURE UUID: 93d3f072-2d42-4d92-bf4f-c5ba8634cb5d
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Date deposited: 05 Mar 2010
Last modified: 18 Mar 2024 02:48
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Author:
S.J. Simmonds
Author:
H.J. Martin
Author:
C. Watson
Author:
A.A. Sayer
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