Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study.
Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study.
Summary: We utilised the Hertfordshire cohort study to examine relationships between bone density at baseline and SF-36 status 4 years later. We found deterioration in the mental health domain over follow-up in osteoporotic men (but not women) compared with other groups (relative rate ratio?=?5.78, 95% confidence interval (CI) 1.78–19.2).
Introduction: Osteoporosis is associated with decreased quality of life, although it has been difficult to evaluate the confounding effects of fracture and co-morbidity. Having previously shown that male osteoporotics have poorer health than counterparts with normal bone mineral density, even after adjustment for co-morbidity and prior fracture, we assessed quality of life in both groups 4 years apart.
Methods: Four hundred and ninety-eight men and 468 women completed questionnaires detailing lifestyle factors, co-morbidities and quality of life (SF-36) before undergoing bone density measurements at the lumbar spine and total femur. At follow-up 4 years later, 322 men and 320 women were reassessed.
Results: Multinomial logistic regression confirmed deterioration in mental health over follow-up in osteoporotic men compared with other groups (relative rate ratio?=?5.78, 95% CI 1.78–19.2). These patterns were not apparent among women.
Conclusions Men with lower bone density at baseline had poorer quality of life some 4 years later, even after adjustment for co-morbidity and fracture. This may reflect secondary osteoporosis in men (due to alcohol or hypogonadism).
Bone, Men, Osteoporosis, Quality of life, Women
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Jameson, K.A.
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Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Martin, H.J.
34384528-4b85-41c3-95dc-16ade10aaf44
Cushnaghan, J.
fb4ffb9b-caf7-42f5-8fb2-5ce279d4ef2b
Aihie Sayer, A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
19 December 2009
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Jameson, K.A.
d5fb142d-06af-456e-9016-17497f94e9f2
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Martin, H.J.
34384528-4b85-41c3-95dc-16ade10aaf44
Cushnaghan, J.
fb4ffb9b-caf7-42f5-8fb2-5ce279d4ef2b
Aihie Sayer, A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M., Jameson, K.A., Syddall, H.E., Martin, H.J., Cushnaghan, J., Aihie Sayer, A. and Cooper, C.
(2009)
Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study.
Osteoporosis International.
(doi:10.1007/s00198-009-1147-z).
Abstract
Summary: We utilised the Hertfordshire cohort study to examine relationships between bone density at baseline and SF-36 status 4 years later. We found deterioration in the mental health domain over follow-up in osteoporotic men (but not women) compared with other groups (relative rate ratio?=?5.78, 95% confidence interval (CI) 1.78–19.2).
Introduction: Osteoporosis is associated with decreased quality of life, although it has been difficult to evaluate the confounding effects of fracture and co-morbidity. Having previously shown that male osteoporotics have poorer health than counterparts with normal bone mineral density, even after adjustment for co-morbidity and prior fracture, we assessed quality of life in both groups 4 years apart.
Methods: Four hundred and ninety-eight men and 468 women completed questionnaires detailing lifestyle factors, co-morbidities and quality of life (SF-36) before undergoing bone density measurements at the lumbar spine and total femur. At follow-up 4 years later, 322 men and 320 women were reassessed.
Results: Multinomial logistic regression confirmed deterioration in mental health over follow-up in osteoporotic men compared with other groups (relative rate ratio?=?5.78, 95% CI 1.78–19.2). These patterns were not apparent among women.
Conclusions Men with lower bone density at baseline had poorer quality of life some 4 years later, even after adjustment for co-morbidity and fracture. This may reflect secondary osteoporosis in men (due to alcohol or hypogonadism).
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Submitted date: 10 September 2009
Published date: 19 December 2009
Keywords:
Bone, Men, Osteoporosis, Quality of life, Women
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Local EPrints ID: 73569
URI: http://eprints.soton.ac.uk/id/eprint/73569
ISSN: 0937-941X
PURE UUID: 6295d79d-0c4e-468d-ba35-b1323fdce8e2
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Date deposited: 09 Mar 2010
Last modified: 18 Mar 2024 02:48
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Author:
H.J. Martin
Author:
J. Cushnaghan
Author:
A. Aihie Sayer
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