Asherman syndrome--one century later

Yu, Dan, Wong, Yat-May, Cheong, Ying, Xia, Enlan and Li, Tin-Chiu (2008) Asherman syndrome--one century later. Fertility and Sterility, 89, (4), 759-779. (doi:10.1016/j.fertnstert.2008.02.096).


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Objective: To provide an update on the current knowledge of Asherman syndrome.


Literature review.


The worldwide reports of this disease.


Patients with Asherman syndrome who presented with amenorrhea or hypomenorrhea, infertility, or recurrent pregnancy loss.


Hysteroscopy and hysteroscopic surgery have been the gold standard of diagnosis and treatment respectively for this condition.

Main outcome measure(s):

The etiology, pathology, symptomatology, diagnosis, treatment, and reproductive outcomes were analyzed.


This syndrome occurs mainly as a result of trauma to the gravid uterine cavity, which leads to the formation of intrauterine and/or intracervical adhesions. Despite the advances in hysteroscopic surgery, the treatment of moderate to severe Asherman syndrome still presents a challenge. Furthermore, pregnancy after treatment remains high risk with complications including spontaneous abortion, preterm delivery, intrauterine growth restriction, placenta accrete or praevia, or even uterine rupture.


The management of moderate to severe disease still poses a challenge, and the prognosis of severe disease remains poor. Close antenatal surveillance and monitoring are necessary for women who conceive after treatment.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.fertnstert.2008.02.096
Additional Information: PMID: 18406834 [PubMed - indexed for MEDLINE]
ISSNs: 0015-0282 (print)
Related URLs:
Keywords: Intrauterine adhesion, asherman syndrome, hysteroscopic adhesiolysis, infertility, synechia, hysteroscopy, amenorrhea
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 76224
Accepted Date and Publication Date:
April 2008Published
Date Deposited: 15 Mar 2010
Last Modified: 31 Mar 2016 13:09

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