Integrated optical Mach-Zehnder interferometer as simazine immunoprobe


Drapp, B., Piehler, J., Brecht, A., Gauglitz, G., Luff, B.J., Wilkinson, J.S. and Ingenhoff, J. (1997) Integrated optical Mach-Zehnder interferometer as simazine immunoprobe. Sensors and Actuators B: Chemical, 39, (1-3), 277-282. (PMID:10.1016/S0925-4005(97)80218-3).

Download

[img] PDF - Pre print
Download (320Kb)

Description/Abstract

Immunoassay has become a versatile tool in several fields of analytical chemistry. We describe the characterization and the application of different integrated optical channel waveguide Mach-Zehnder interferometers (MZIs) as label-free immunoprobes. The performance of the classical MZI is compared with that of a modified structure which incorporates a 3x3 coupler. Characterization of the devices demonstrates a dramatic improvement gained by using the 3x3 coupler. Two main advantages are achieved by the modified device. First, the possibility of referencing the output signal allows the elimination of signal fluctuations due to coupling and light-source instabilities. An increase of the signal-to-noise ratio by a factor of up to 10 is achieved. Secondly, the phase shift between the three outputs allows unambiguous detection with optimum sensitivity. For the detection of the herbicide simazine, the functional properties of the transducer surface are optimized by an appropriate chemical modification. Using this improved device, a simazine immunoassay has been carried out with a test midpoint of 0.3 ppb and a detection limit of approximately 0.1 ppb. The excellent performance, established manufacturing techniques and the potential for simplification and parallelization make the device attractive for further development

Item Type: Article
Additional Information: 3rd European Conference on Optical Chemical Sensors and Biosensors
ISSNs: 0925-4005
Related URLs:
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering
Q Science > QC Physics
Divisions: University Structure - Pre August 2011 > Optoelectronics Research Centre
ePrint ID: 78058
Date Deposited: 11 Mar 2010
Last Modified: 27 Mar 2014 18:58
URI: http://eprints.soton.ac.uk/id/eprint/78058

Actions (login required)

View Item View Item

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics