T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut
Thomas, R., Schurmann, G., Lionetti, P., Pender, S.L.F. and MacDonald, T.T. (1996) T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut. Gut, 38, (2), 190-195. (doi:10.1136/gut.38.2.190 ).
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Description/Abstract
A panel of T cell receptor V beta specific monoclonal antibodies was used to analyse V beta gene usage at different sites in human postnatal and fetal intestine. In normal small intestine, at a single site, different patients showed expansion of T cells expressing individual V beta s. Lamina propria and epithelial T cells from the same patient showed overlapping but not identical V beta dominance. V beta dominance was also shown in the T cells of the colonic lamina propria. Analysis of two separate regions of intestine from the same patient (5-100 cm apart) showed that T cells expressing a dominant V beta region were often present at both sites. In most patients, however, major biases in T cell V beta usage (two to 12-fold variation) were also apparent between the two sites. Analysis of V beta expression in human fetal intestine also showed considerable skewing, although the most common dominant V beta in postnatal intestine (V beta 22) was never predominant in fetal intestine. Patchy local variation in the expression of individual V beta s therefore occurs against a background of V beta dominance over large regions of the human gut. Furthermore the results from fetal gut show that factors other than luminal antigen control V beta expression in the gut.
| Item Type: | Article |
|---|---|
| ISSNs: | 1468-3288 (electronic) |
| Related URLs: | |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair |
| Item ID: | 79332 |
| Date Deposited: | 11 Mar 2010 |
| Last Modified: | 09 Aug 2012 23:39 |
| Contributors: | Thomas, R. (Author) Schurmann, G. (Author) Lionetti, P. (Author) Pender, S.L.F. (Author) MacDonald, T.T. (Author) |
| Date: | February 1996 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/79332 |
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