Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic locicontrolling fetal haemoglobin
Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic locicontrolling fetal haemoglobin
High levels of fetal haemoglobin (HbF) are protective in ?-haemoglobinopathies. The proportion of erythrocytes containing HbF (F-cells, FC) was measured in healthy adults of African and Caucasian ancestry to assess the feasibility of localizing genes for the FC trait using admixture mapping. Participants were Afro-Caribbean (AC) blood donors and residents of a rural enclave with a history of recent German admixture (Afro-German, AG) recruited in Jamaica, and Caucasian Europeans recruited in Jamaica and the UK. FC levels were significantly different between groups (P < 0·001); the geometric mean FC level in the AC sample (n = 176) was 3·75% [95% confidence interval (CI) 3·36–4·18], AG sample (n = 631) was 2·77% (95% CI 2·63–2·92), and among Caucasians (n = 1099) was 3·26% (95% CI 3·13–3·39). After adjustment for age, sex, haemoglobin electrophoresis pattern, and HBG2 genotype, FC levels in the AC group remained significantly different (P < 0·001) from those in the Caucasian and the AG group but the difference between the Caucasian and AG groups became non-significant (P = 0·46) despite substantial differences in average ancestry. The data confirm ethnic differences in FC levels and indicate the potential usefulness of these populations for admixture mapping of genes for FC levels
fetal haemoglobin, F cells, admixture linkage disequilibrium mapping
954-960
Creary, Lisa E.
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McKenzie, Colin A.
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Menzel, Stephan
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Hanchard, Neil A.
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Taylor, Veronica
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Hambleton, Ian
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Spector, Tim D.
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Forrester, Terrence E.
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Thein, Swee Lay
496d02c6-084c-4778-ba43-abbcc667e0da
March 2009
Creary, Lisa E.
414eb1fd-6397-4898-a43f-dc35943dc1cf
McKenzie, Colin A.
c3c47143-2635-4436-b168-0d911d08825f
Menzel, Stephan
5c8f3f55-d218-4f7f-8ef2-0fd0ea13d44c
Hanchard, Neil A.
cd9bbf22-9bc0-4644-91de-7f0510c6491d
Taylor, Veronica
8dedb6fd-a7e2-4e53-9f4a-d2a1c58ff1db
Hambleton, Ian
312403da-660a-44ba-9e1a-3355d1491410
Spector, Tim D.
1e47066c-6620-4f86-af6f-89d9e130ffc2
Forrester, Terrence E.
d5ed0294-0713-4521-baf9-923f1cae5e7f
Thein, Swee Lay
496d02c6-084c-4778-ba43-abbcc667e0da
Creary, Lisa E., McKenzie, Colin A., Menzel, Stephan, Hanchard, Neil A., Taylor, Veronica, Hambleton, Ian, Spector, Tim D., Forrester, Terrence E. and Thein, Swee Lay
(2009)
Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic locicontrolling fetal haemoglobin.
British Journal of Haematology, 144 (6), .
(doi:10.1111/j.1365-2141.2008.07532.x).
Abstract
High levels of fetal haemoglobin (HbF) are protective in ?-haemoglobinopathies. The proportion of erythrocytes containing HbF (F-cells, FC) was measured in healthy adults of African and Caucasian ancestry to assess the feasibility of localizing genes for the FC trait using admixture mapping. Participants were Afro-Caribbean (AC) blood donors and residents of a rural enclave with a history of recent German admixture (Afro-German, AG) recruited in Jamaica, and Caucasian Europeans recruited in Jamaica and the UK. FC levels were significantly different between groups (P < 0·001); the geometric mean FC level in the AC sample (n = 176) was 3·75% [95% confidence interval (CI) 3·36–4·18], AG sample (n = 631) was 2·77% (95% CI 2·63–2·92), and among Caucasians (n = 1099) was 3·26% (95% CI 3·13–3·39). After adjustment for age, sex, haemoglobin electrophoresis pattern, and HBG2 genotype, FC levels in the AC group remained significantly different (P < 0·001) from those in the Caucasian and the AG group but the difference between the Caucasian and AG groups became non-significant (P = 0·46) despite substantial differences in average ancestry. The data confirm ethnic differences in FC levels and indicate the potential usefulness of these populations for admixture mapping of genes for FC levels
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Published date: March 2009
Keywords:
fetal haemoglobin, F cells, admixture linkage disequilibrium mapping
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Local EPrints ID: 79358
URI: http://eprints.soton.ac.uk/id/eprint/79358
ISSN: 0007-1048
PURE UUID: c4d4d1a4-b1e3-49e2-8621-09277d9b31b1
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Date deposited: 15 Mar 2010
Last modified: 14 Mar 2024 00:29
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Author:
Lisa E. Creary
Author:
Colin A. McKenzie
Author:
Stephan Menzel
Author:
Neil A. Hanchard
Author:
Veronica Taylor
Author:
Ian Hambleton
Author:
Tim D. Spector
Author:
Terrence E. Forrester
Author:
Swee Lay Thein
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