MicroRNAs: key players in carcinogenesis and novel therapeutic targets
Mirnezami, A. H. F, Pickard, K., Zhang, L., Primrose, J. N. and Packham, G. (2008) MicroRNAs: key players in carcinogenesis and novel therapeutic targets. European Journal of Surgical Oncology, 35, (4), 339-347. (doi:10.1016/j.ejso.2008.06.006).
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MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype.
The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide.
|Keywords:||MicroRNA, molecular profiling, cancer, clinical utility|
|Subjects:||R Medicine > RD Surgery|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||15 Mar 2010|
|Last Modified:||06 Aug 2015 02:59|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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