MicroRNAs: key players in carcinogenesis and novel therapeutic targets

Mirnezami, A. H. F, Pickard, K., Zhang, L., Primrose, J. N. and Packham, G. (2008) MicroRNAs: key players in carcinogenesis and novel therapeutic targets. European Journal of Surgical Oncology, 35, (4), 339-347. (doi:10.1016/j.ejso.2008.06.006).


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MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype.

The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.ejso.2008.06.006
ISSNs: 0748-7983 (print)
Related URLs:
Keywords: MicroRNA, molecular profiling, cancer, clinical utility
Subjects: R Medicine > RD Surgery
Divisions : University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
ePrint ID: 79414
Accepted Date and Publication Date:
April 2008Published
Date Deposited: 15 Mar 2010
Last Modified: 31 Mar 2016 13:15
URI: http://eprints.soton.ac.uk/id/eprint/79414

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