Multiple micronutrient supplementation during pregnancy in low-income countries: review of methods and characteristics of studies included in the meta-analyses
Multiple micronutrient supplementation during pregnancy in low-income countries: review of methods and characteristics of studies included in the meta-analyses
Background: Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes.
Objective: To conduct a meta-analysis of the effects on stillbirths and on early and late neonatal mortality of supplementation during pregnancy with multiple micronutrients compared with iron-folic acid in recent randomized, controlled trials.
Methods: Twelve randomized, controlled trials were included in the analysis (Bangladesh; Burkina Faso; China; Guinea-Bissau; Indramayu and Lombok, Indonesia; Mexico; Sarlahi and Janakur, Nepal; Niger; Pakistan; and Zimbabwe), all providing approximately 1 recommended dietary allowance (RDA) of multiple micronutrients or iron-folic acid to presumed HIV-negative women.
Results: Supplementation providing approximately I RDA of multiple micronutrients did not decrease the risk of stillbirth (OR = 1.01; 95% CI, 0.88 to 1.16), early neonatal mortality (OR = 1.23; 95% CI, 0.95 to 1.59), late neonatal mortality (OR = 0.94; 95% CI, 0.73 to 1.23), or perinatal mortality (OR = 1.11; 95% CI, 0.93 to 1.33).
Conclusions: Our meta-analysis provides consistent evidence that supplementation providing approximately 1 RDA of multiple micronutrients during pregnancy does not result in any reduction in stillbirths or in early or late neonatal deaths compared with iron-folic acid alone.
birth weight, dietary supplements, fetal development, micronutrients, pregnancy complications
S547-S555
Margetts, Barrie M.
d415f4a1-d572-4ebc-be25-f54886cb4788
Fall, Caroline H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Ronsmans, Carine
d6a42eeb-721b-457d-b55f-d32c6e901b4a
Allen, Lindsay H.
70e82f40-c465-497b-9691-f8267a6ff26e
Fisher, David J.
07d31716-65e3-48eb-af44-471428b7e003
Maternal Micronutrient Supplementation Study Group
December 2009
Margetts, Barrie M.
d415f4a1-d572-4ebc-be25-f54886cb4788
Fall, Caroline H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Ronsmans, Carine
d6a42eeb-721b-457d-b55f-d32c6e901b4a
Allen, Lindsay H.
70e82f40-c465-497b-9691-f8267a6ff26e
Fisher, David J.
07d31716-65e3-48eb-af44-471428b7e003
Margetts, Barrie M., Fall, Caroline H.D., Ronsmans, Carine, Allen, Lindsay H. and Fisher, David J.
,
Maternal Micronutrient Supplementation Study Group
(2009)
Multiple micronutrient supplementation during pregnancy in low-income countries: review of methods and characteristics of studies included in the meta-analyses.
Food and Nutrition Bulletin, 30 (4), .
Abstract
Background: Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes.
Objective: To conduct a meta-analysis of the effects on stillbirths and on early and late neonatal mortality of supplementation during pregnancy with multiple micronutrients compared with iron-folic acid in recent randomized, controlled trials.
Methods: Twelve randomized, controlled trials were included in the analysis (Bangladesh; Burkina Faso; China; Guinea-Bissau; Indramayu and Lombok, Indonesia; Mexico; Sarlahi and Janakur, Nepal; Niger; Pakistan; and Zimbabwe), all providing approximately 1 recommended dietary allowance (RDA) of multiple micronutrients or iron-folic acid to presumed HIV-negative women.
Results: Supplementation providing approximately I RDA of multiple micronutrients did not decrease the risk of stillbirth (OR = 1.01; 95% CI, 0.88 to 1.16), early neonatal mortality (OR = 1.23; 95% CI, 0.95 to 1.59), late neonatal mortality (OR = 0.94; 95% CI, 0.73 to 1.23), or perinatal mortality (OR = 1.11; 95% CI, 0.93 to 1.33).
Conclusions: Our meta-analysis provides consistent evidence that supplementation providing approximately 1 RDA of multiple micronutrients during pregnancy does not result in any reduction in stillbirths or in early or late neonatal deaths compared with iron-folic acid alone.
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Published date: December 2009
Keywords:
birth weight, dietary supplements, fetal development, micronutrients, pregnancy complications
Identifiers
Local EPrints ID: 79419
URI: http://eprints.soton.ac.uk/id/eprint/79419
ISSN: 0379-5721
PURE UUID: dbbac6d1-6d39-4d7f-914e-bda60335c8a0
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Date deposited: 15 Mar 2010
Last modified: 23 Jul 2022 01:33
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Contributors
Author:
Carine Ronsmans
Author:
Lindsay H. Allen
Author:
David J. Fisher
Corporate Author: Maternal Micronutrient Supplementation Study Group
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