Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on stillbirths and on early and late neonatal mortality


Ronsmans, Carine, Fisher, David J., Osmond, Clive, Margetts, Barrie M. and Fall, Caroline H.D. Maternal Micronutrient Supplementation Study Group MMSG (2009) Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on stillbirths and on early and late neonatal mortality. [in special issue: Multiple Micronutrient Supplementation During Pregnancy in Developing Country Settings] Food and Nutrition Bulletin, 30, supplement 4, S547-S555. (PMID:20120796).

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Description/Abstract

Background: multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes.

Objective: to conduct a meta-analysis of the effects on stillbirths and on early and late neonatal mortality of supplementation during pregnancy with multiple micronutrients compared with iron-folic acid in recent randomized, controlled trials.

Methods: twelve randomized, controlled trials were included in the analysis (Bangladesh; Burkina Faso; China; Guinea-Bissau; Indramayu and Lombok, Indonesia; Mexico; Sarlahi and Janakur, Nepal; Niger; Pakistan; and Zimbabwe), all providing approximately 1 recommended dietary allowance (RDA) of multiple micronutrients or iron-folic acid to presumed HIV-negative women.

Results: supplementation providing approximately I RDA of multiple micronutrients did not decrease the risk of stillbirth (OR = 1.01; 95% CI, 0.88 to 1.16), early neonatal mortality (OR = 1.23; 95% CI, 0.95 to 1.59), late neonatal mortality (OR = 0.94; 95% CI, 0.73 to 1.23), or perinatal mortality (OR = 1.11; 95% CI, 0.93 to 1.33).

Conclusions: our meta-analysis provides consistent evidence that supplementation providing approximately 1 RDA of multiple micronutrients during pregnancy does not result in any reduction in stillbirths or in early or late neonatal deaths compared with iron-folic acid alone.

Item Type: Article
ISSNs: 0379-5721 (print)
1564-8265 (electronic)
Related URLs:
Subjects: R Medicine > RG Gynecology and obstetrics
H Social Sciences > HC Economic History and Conditions
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 79421
Date Deposited: 16 Mar 2010
Last Modified: 27 Mar 2014 19:01
Contact Email Address: chdf@mrc.soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/79421

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