Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk
Barrett-Lee, P J, Dixon, J M, Farrell, C, Jones, A, Leonard, R, Murray, N, Palmieri, C, Plummer, C J, Stanley, A and Verrill, M W (2009) Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk. Annals of Oncology, 20, 816-827. (doi:10.1093/annonc/mdn728)
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Description/Abstract
Anthracyclines are considered to be among the most active agents for the treatment of breast cancer. However, their use is limited by cumulative, dose-related cardiotoxicity. Such cardiotoxicity results in a permanent loss of cardiac myocytes and a progressive reduction in cardiac function following each subsequent dose of anthracycline. Initially, damage to the heart is subclinical; however, increasingly impaired cardiac function can result in cardiovascular symptoms, with serious cardiac injury resulting in chronic heart failure. Since the early detection and treatment of cardiotoxicity can reduce its clinical effects, it is important that oncologists are aware of these adverse effects and manage them appropriately. This review examines the risk factors for anthracycline-associated cardiotoxicity and offers recommendations on strategies to reduce the cardiotoxicity of anthracyclines in the management of patients with advanced breast cancer.
| Item Type: | Article |
|---|---|
| ISSN: | 0923-7534 (print) |
| Uncontrolled Keywords: | advanced breast cancer, anthracyclines, cardiac monitoring, cardiotoxicity, liposomal anthracyclines, risk factors |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences University Structure - Pre August 2011 > School of Medicine |
| ePrint ID: | 79468 |
| URI: | http://eprints.soton.ac.uk/id/eprint/79468 |
| Deposited On: | 16 Mar 2010 |
| Last Modified: | 01 Jun 2011 16:14 |
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