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N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells]

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells]
N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells]
Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix metalloproteinase (MMP) inhibition. This has led to further study of novel substrates for MMPs that might impact on HSC survival. N-Cadherin is known to mediate cell-cell contacts in fibroblasts. In this study we demonstrate that N-Cadherin is expressed by activated rat HSC. Furthermore, during apoptosis of HSC, the N-Cadherin is cleaved into smaller fragments. Apoptosis of HSC may be inhibited by TIMP-1. This is associated with reduced fragmentation of N-Cadherin. N-Cadherin may have an important role in supporting HSC survival while N-Cadherin cleavage may play a part in promoting HSC apoptosis in recovery from liver fibrosis.
1476-5926
p.S8
Murphy, Frank
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Waung, Julian
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Collins, Jane
be0e66f1-3036-47fa-9d7e-914c48710ba4
Arthur, Michael J.P.
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Nagase, Hideaki
5779c4fb-15cd-4176-99f7-b9bc0c47aa49
Mann, Derek
c715dfce-27ed-4696-8b51-5b9cc086f4b8
Benyon, R. Christopher
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Iredale, John P.
607673ce-77b2-4418-b317-2aa778110ee2
Murphy, Frank
e930f640-f880-4fc6-9f54-376a2d8aace7
Waung, Julian
4677968e-251e-42ef-bfe6-4bca722137ee
Collins, Jane
be0e66f1-3036-47fa-9d7e-914c48710ba4
Arthur, Michael J.P.
d61d056b-6470-4afc-bafb-7a20be9cc413
Nagase, Hideaki
5779c4fb-15cd-4176-99f7-b9bc0c47aa49
Mann, Derek
c715dfce-27ed-4696-8b51-5b9cc086f4b8
Benyon, R. Christopher
6efa9278-56e6-47ec-9854-78afd98dd4c9
Iredale, John P.
607673ce-77b2-4418-b317-2aa778110ee2

Murphy, Frank, Waung, Julian, Collins, Jane, Arthur, Michael J.P., Nagase, Hideaki, Mann, Derek, Benyon, R. Christopher and Iredale, John P. (2004) N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells]. Comparative Hepatology, 3 (Suppl 1), p.S8. (doi:10.1186/1476-5926-2-S1-S8).

Record type: Article

Abstract

Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix metalloproteinase (MMP) inhibition. This has led to further study of novel substrates for MMPs that might impact on HSC survival. N-Cadherin is known to mediate cell-cell contacts in fibroblasts. In this study we demonstrate that N-Cadherin is expressed by activated rat HSC. Furthermore, during apoptosis of HSC, the N-Cadherin is cleaved into smaller fragments. Apoptosis of HSC may be inhibited by TIMP-1. This is associated with reduced fragmentation of N-Cadherin. N-Cadherin may have an important role in supporting HSC survival while N-Cadherin cleavage may play a part in promoting HSC apoptosis in recovery from liver fibrosis.

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Published date: 14 January 2004
Additional Information: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells Tucson, Arizona, USA, 25–29 August, 2002.

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Local EPrints ID: 8191
URI: http://eprints.soton.ac.uk/id/eprint/8191
ISSN: 1476-5926
PURE UUID: 4e371558-d654-410f-8491-9d31a74a2eb1

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Date deposited: 10 Aug 2004
Last modified: 15 Mar 2024 04:52

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Contributors

Author: Frank Murphy
Author: Julian Waung
Author: Jane Collins
Author: Michael J.P. Arthur
Author: Hideaki Nagase
Author: Derek Mann
Author: R. Christopher Benyon
Author: John P. Iredale

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