The synthesis and in vivo evaluation of 2,2-difluoro KRN7000
The synthesis and in vivo evaluation of 2,2-difluoro KRN7000
The synthesis of 2,2-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.
galactosylceramide, cytokines, fluorination, glycolipids, NKT cells
329 -334
Leung, Leo
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Tomassi, Cyrille
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Van Beneden, Katrien
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Decruy, Tine
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Trappeniers, Matthias
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Elewaut, Dirk
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Gao, Yifang
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Elliott, Tim
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Al-Shamkhani, Aymen
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Ottensmeier, Christian
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Werner, Jörn M.
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Williams, Anthony
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Van Calenbergh, Serge
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Linclau, Bruno
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16 March 2009
Leung, Leo
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Tomassi, Cyrille
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Van Beneden, Katrien
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Decruy, Tine
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Trappeniers, Matthias
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Elewaut, Dirk
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Gao, Yifang
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Elliott, Tim
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Al-Shamkhani, Aymen
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Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Werner, Jörn M.
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Williams, Anthony
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Van Calenbergh, Serge
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Linclau, Bruno
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Leung, Leo, Tomassi, Cyrille, Van Beneden, Katrien, Decruy, Tine, Trappeniers, Matthias, Elewaut, Dirk, Gao, Yifang, Elliott, Tim, Al-Shamkhani, Aymen, Ottensmeier, Christian, Werner, Jörn M., Williams, Anthony, Van Calenbergh, Serge and Linclau, Bruno
(2009)
The synthesis and in vivo evaluation of 2,2-difluoro KRN7000.
ChemMedChem, 4 (3), .
(doi:10.1002/cmdc.200800348).
Abstract
The synthesis of 2,2-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.
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Published date: 16 March 2009
Keywords:
galactosylceramide, cytokines, fluorination, glycolipids, NKT cells
Organisations:
Cancer Sciences
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Local EPrints ID: 148257
URI: http://eprints.soton.ac.uk/id/eprint/148257
ISSN: 1860-7179
PURE UUID: f21db676-d572-4399-90d6-b040c9505aec
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Date deposited: 27 Apr 2010 14:20
Last modified: 14 Mar 2024 02:48
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Author:
Leo Leung
Author:
Cyrille Tomassi
Author:
Katrien Van Beneden
Author:
Tine Decruy
Author:
Matthias Trappeniers
Author:
Dirk Elewaut
Author:
Yifang Gao
Author:
Serge Van Calenbergh
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