The University of Southampton
University of Southampton Institutional Repository

The synthesis and in vivo evaluation of 2,2-difluoro KRN7000

The synthesis and in vivo evaluation of 2,2-difluoro KRN7000
The synthesis and in vivo evaluation of 2,2-difluoro KRN7000
The synthesis of 2,2-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.
galactosylceramide, cytokines, fluorination, glycolipids, NKT cells
1860-7179
329 -334
Leung, Leo
bc749c61-15c6-4c7c-9396-db2c93ac3fd9
Tomassi, Cyrille
51fbf42e-4b91-481c-8528-95ca06e30c40
Van Beneden, Katrien
d8fc2c97-163b-4422-a513-34a08745a00c
Decruy, Tine
0d799625-7310-423a-b7a7-6ece86b8ea1a
Trappeniers, Matthias
003338a8-2d89-453c-86ee-67c7464e1ac3
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Gao, Yifang
d209d667-ef6e-4a24-ab7d-2f52c618361f
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Al-Shamkhani, Aymen
0a40b3ce-9d71-4d41-9369-7212f0a84504
Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Werner, Jörn M.
1b02513a-8310-4f4f-adac-dc2a466bd115
Williams, Anthony
973ff46f-46f1-4d7c-b27d-0f53221e4c44
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Leung, Leo
bc749c61-15c6-4c7c-9396-db2c93ac3fd9
Tomassi, Cyrille
51fbf42e-4b91-481c-8528-95ca06e30c40
Van Beneden, Katrien
d8fc2c97-163b-4422-a513-34a08745a00c
Decruy, Tine
0d799625-7310-423a-b7a7-6ece86b8ea1a
Trappeniers, Matthias
003338a8-2d89-453c-86ee-67c7464e1ac3
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Gao, Yifang
d209d667-ef6e-4a24-ab7d-2f52c618361f
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Al-Shamkhani, Aymen
0a40b3ce-9d71-4d41-9369-7212f0a84504
Ottensmeier, Christian
42b8a398-baac-4843-a3d6-056225675797
Werner, Jörn M.
1b02513a-8310-4f4f-adac-dc2a466bd115
Williams, Anthony
973ff46f-46f1-4d7c-b27d-0f53221e4c44
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba

Leung, Leo, Tomassi, Cyrille, Van Beneden, Katrien, Decruy, Tine, Trappeniers, Matthias, Elewaut, Dirk, Gao, Yifang, Elliott, Tim, Al-Shamkhani, Aymen, Ottensmeier, Christian, Werner, Jörn M., Williams, Anthony, Van Calenbergh, Serge and Linclau, Bruno (2009) The synthesis and in vivo evaluation of 2,2-difluoro KRN7000. ChemMedChem, 4 (3), 329 -334. (doi:10.1002/cmdc.200800348).

Record type: Article

Abstract

The synthesis of 2,2-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.

This record has no associated files available for download.

More information

Published date: 16 March 2009
Keywords: galactosylceramide, cytokines, fluorination, glycolipids, NKT cells
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 148257
URI: http://eprints.soton.ac.uk/id/eprint/148257
ISSN: 1860-7179
PURE UUID: f21db676-d572-4399-90d6-b040c9505aec
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222
ORCID for Aymen Al-Shamkhani: ORCID iD orcid.org/0000-0003-0727-4189
ORCID for Jörn M. Werner: ORCID iD orcid.org/0000-0002-4712-1833
ORCID for Bruno Linclau: ORCID iD orcid.org/0000-0001-8762-0170

Catalogue record

Date deposited: 27 Apr 2010 14:20
Last modified: 14 Mar 2024 02:48

Export record

Altmetrics

Contributors

Author: Leo Leung
Author: Cyrille Tomassi
Author: Katrien Van Beneden
Author: Tine Decruy
Author: Matthias Trappeniers
Author: Dirk Elewaut
Author: Yifang Gao
Author: Tim Elliott ORCID iD
Author: Jörn M. Werner ORCID iD
Author: Serge Van Calenbergh
Author: Bruno Linclau ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×