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Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis

Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis
Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis
Recent studies in alcoholic hepatitis have proposed a role for the cytokine tumour necrosis factor-alpha (TNF-alpha) a mediator of endotoxic shock in sepsis. In this study plasma levels of the closely related cytokine interleukin-6 (IL-6) were assayed in 96 samples from 58 patients with severe alcoholic hepatitis, and 69 patients in control groups (21 normal, 10 alcoholic without liver disease, 10 inactive alcoholic cirrhosis, 18 chronic liver disease, 10 chronic renal failure). Plasma IL-6 levels were markedly elevated in patients with alcoholic hepatitis when compared with all control groups (P less than 0.001). IL-6 levels were higher in patients who died (P = 0.04) and correlated with the features of severe disease including: increased grade of encephalopathy, increased neutrophil count, increased prothrombin ratio, hypotension, increased serum creatinine and increased serum bilirubin. Surprisingly, no correlation was found between levels of plasma IL-6 and plasma TNF-alpha or endotoxin, or the presence of infection; an inverse correlation was found between plasma IL-6 and serum globulins. These findings provide further evidence that the IL-6/TNF cytokine system is activated in severe alcoholic hepatitis and may mediate hepatic or extra-hepatic tissue damage.
0009-9104
449-453
Sheron, N.
cbf852e3-cfaa-43b2-ab99-a954d96069f1
Bird, G.
2f6a3629-57e8-4dd2-9ba8-6be124dae20d
Goka, J.
157fa443-649d-4054-95f9-f754d9048074
Alexander, G.J.M.
33154574-e14c-4ac3-ae5e-f5983b531348
Williams, R.
49181762-00c1-4043-9247-a9bcddbd04f7
Sheron, N.
cbf852e3-cfaa-43b2-ab99-a954d96069f1
Bird, G.
2f6a3629-57e8-4dd2-9ba8-6be124dae20d
Goka, J.
157fa443-649d-4054-95f9-f754d9048074
Alexander, G.J.M.
33154574-e14c-4ac3-ae5e-f5983b531348
Williams, R.
49181762-00c1-4043-9247-a9bcddbd04f7

Sheron, N., Bird, G., Goka, J., Alexander, G.J.M. and Williams, R. (1991) Elevated plasma interleukin-6 and increased severity and mortality in alcoholic hepatitis. Clinical and Experimental Immunology, 84 (3), 449-453.

Record type: Article

Abstract

Recent studies in alcoholic hepatitis have proposed a role for the cytokine tumour necrosis factor-alpha (TNF-alpha) a mediator of endotoxic shock in sepsis. In this study plasma levels of the closely related cytokine interleukin-6 (IL-6) were assayed in 96 samples from 58 patients with severe alcoholic hepatitis, and 69 patients in control groups (21 normal, 10 alcoholic without liver disease, 10 inactive alcoholic cirrhosis, 18 chronic liver disease, 10 chronic renal failure). Plasma IL-6 levels were markedly elevated in patients with alcoholic hepatitis when compared with all control groups (P less than 0.001). IL-6 levels were higher in patients who died (P = 0.04) and correlated with the features of severe disease including: increased grade of encephalopathy, increased neutrophil count, increased prothrombin ratio, hypotension, increased serum creatinine and increased serum bilirubin. Surprisingly, no correlation was found between levels of plasma IL-6 and plasma TNF-alpha or endotoxin, or the presence of infection; an inverse correlation was found between plasma IL-6 and serum globulins. These findings provide further evidence that the IL-6/TNF cytokine system is activated in severe alcoholic hepatitis and may mediate hepatic or extra-hepatic tissue damage.

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Published date: 1991

Identifiers

Local EPrints ID: 154581
URI: http://eprints.soton.ac.uk/id/eprint/154581
ISSN: 0009-9104
PURE UUID: db2b7974-76f2-4cfe-976e-92037552d011
ORCID for N. Sheron: ORCID iD orcid.org/0000-0001-5232-8292

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Date deposited: 14 Jul 2010 16:33
Last modified: 22 Jul 2022 17:26

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Contributors

Author: N. Sheron ORCID iD
Author: G. Bird
Author: J. Goka
Author: G.J.M. Alexander
Author: R. Williams

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