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Leukotriene and prostaglandin production following infusion of tumour necrosis factor in man

Leukotriene and prostaglandin production following infusion of tumour necrosis factor in man
Leukotriene and prostaglandin production following infusion of tumour necrosis factor in man
Tumor necrosis factor-alpha is believed to be an important mediator of endotoxaemia and septic shock, the effects of which are thought to be mediated through the generation of cysteinyl-leukotrienes, thromboxane A2 and other prostanoids. We have investigated the production of these eicosanoids and also that of prostacyclin in vivo after infusion of tumor necrosis factor-alpha into 4 subjects with a chronic hepatitis B virus infection. This resulted in plasma TNF levels considerably greater than those observed in septic shock. Urinary excretion rate of leukotriene E4 increased by 2 to 3-fold in all subjects by 8 h following TNF infusion. Urinary excretion of thromboxane B2 and 6-oxo-prostaglandin F1 alpha, however, increased in the first 4 h in 3/4 subjects by 2 to 40-fold and returned towards baseline by 8 h. Excretion of the hepatic metabolite, 2,3-dinor 6-oxo-prostaglandin F1 alpha, increased in all subjects (2 to 4-fold at 4h). We conclude that there is increased production of cysteinyl leukotrienes, thromboxane A2 and prostacyclin after infusion of tumour necrosis factor into man.
0934-9820
115-118
Moore, K.P.
c4dceaea-f05f-4fa5-ba86-9253e3d9b95d
Sheron, Nick
cbf852e3-cfaa-43b2-ab99-a954d96069f1
Ward, P.
be8f5e51-8144-43cf-8c11-e0c7cf87b86c
Taylor, G.W.
9dc5c650-e163-4f33-86f3-c51f81bd22ca
Alexander, G.J.M.
33154574-e14c-4ac3-ae5e-f5983b531348
Williams, R.
49181762-00c1-4043-9247-a9bcddbd04f7
Moore, K.P.
c4dceaea-f05f-4fa5-ba86-9253e3d9b95d
Sheron, Nick
cbf852e3-cfaa-43b2-ab99-a954d96069f1
Ward, P.
be8f5e51-8144-43cf-8c11-e0c7cf87b86c
Taylor, G.W.
9dc5c650-e163-4f33-86f3-c51f81bd22ca
Alexander, G.J.M.
33154574-e14c-4ac3-ae5e-f5983b531348
Williams, R.
49181762-00c1-4043-9247-a9bcddbd04f7

Moore, K.P., Sheron, Nick, Ward, P., Taylor, G.W., Alexander, G.J.M. and Williams, R. (1991) Leukotriene and prostaglandin production following infusion of tumour necrosis factor in man. Eicosanoids, 4 (2), 115-118.

Record type: Article

Abstract

Tumor necrosis factor-alpha is believed to be an important mediator of endotoxaemia and septic shock, the effects of which are thought to be mediated through the generation of cysteinyl-leukotrienes, thromboxane A2 and other prostanoids. We have investigated the production of these eicosanoids and also that of prostacyclin in vivo after infusion of tumor necrosis factor-alpha into 4 subjects with a chronic hepatitis B virus infection. This resulted in plasma TNF levels considerably greater than those observed in septic shock. Urinary excretion rate of leukotriene E4 increased by 2 to 3-fold in all subjects by 8 h following TNF infusion. Urinary excretion of thromboxane B2 and 6-oxo-prostaglandin F1 alpha, however, increased in the first 4 h in 3/4 subjects by 2 to 40-fold and returned towards baseline by 8 h. Excretion of the hepatic metabolite, 2,3-dinor 6-oxo-prostaglandin F1 alpha, increased in all subjects (2 to 4-fold at 4h). We conclude that there is increased production of cysteinyl leukotrienes, thromboxane A2 and prostacyclin after infusion of tumour necrosis factor into man.

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Published date: 1991

Identifiers

Local EPrints ID: 154611
URI: http://eprints.soton.ac.uk/id/eprint/154611
ISSN: 0934-9820
PURE UUID: db183e85-b719-4cf9-a18c-be428e365032
ORCID for Nick Sheron: ORCID iD orcid.org/0000-0001-5232-8292

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Date deposited: 14 Jul 2010 16:29
Last modified: 22 Jul 2022 17:26

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Contributors

Author: K.P. Moore
Author: Nick Sheron ORCID iD
Author: P. Ward
Author: G.W. Taylor
Author: G.J.M. Alexander
Author: R. Williams

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