The University of Southampton
University of Southampton Institutional Repository

Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms

Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms
Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms
Staphylococcus aureus is a common pathogen responsible for nosocomial and community infections. It readily colonizes indwelling catheters, forming microbiotic communities termed biofilms. S. aureus bacteria in biofilms are protected from killing by antibiotics and the body's immune system. For years, one mechanism behind biofilm resistance to attack from the immune system's sentinel leukocytes has been conceptualized as a deficiency in the ability of the leukocytes to penetrate the biofilm. We demonstrate here that under conditions mimicking physiological shear, leukocytes attach, penetrate, and produce cytokines in response to maturing and fully matured S. aureus biofilm.
0019-9567
6339-6345
Leid, Jeff G.
7b095972-1283-4371-b8a6-8cbf667d6b33
Shirtliff, Mark E.
38eb9180-8d02-4f86-bbdb-3f58734604e5
Costerton, J. W.
228b5d89-a8a6-4832-a265-29ce63868a87
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Leid, Jeff G.
7b095972-1283-4371-b8a6-8cbf667d6b33
Shirtliff, Mark E.
38eb9180-8d02-4f86-bbdb-3f58734604e5
Costerton, J. W.
228b5d89-a8a6-4832-a265-29ce63868a87
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f

Leid, Jeff G., Shirtliff, Mark E., Costerton, J. W. and Stoodley, Paul (2002) Human leukocytes adhere to, penetrate, and respond to Staphylococcus aureus biofilms. Infection and Immunity, 70 (11), 6339-6345. (doi:10.1128/IAI.70.11.6339-6345.2002).

Record type: Article

Abstract

Staphylococcus aureus is a common pathogen responsible for nosocomial and community infections. It readily colonizes indwelling catheters, forming microbiotic communities termed biofilms. S. aureus bacteria in biofilms are protected from killing by antibiotics and the body's immune system. For years, one mechanism behind biofilm resistance to attack from the immune system's sentinel leukocytes has been conceptualized as a deficiency in the ability of the leukocytes to penetrate the biofilm. We demonstrate here that under conditions mimicking physiological shear, leukocytes attach, penetrate, and produce cytokines in response to maturing and fully matured S. aureus biofilm.

This record has no associated files available for download.

More information

Published date: November 2002
Organisations: Engineering Mats & Surface Engineerg Gp

Identifiers

Local EPrints ID: 157139
URI: http://eprints.soton.ac.uk/id/eprint/157139
ISSN: 0019-9567
PURE UUID: 0300ad71-8cb0-4e0d-97de-604a3d0b43b4
ORCID for Paul Stoodley: ORCID iD orcid.org/0000-0001-6069-273X

Catalogue record

Date deposited: 09 Jun 2010 14:29
Last modified: 14 Mar 2024 02:55

Export record

Altmetrics

Contributors

Author: Jeff G. Leid
Author: Mark E. Shirtliff
Author: J. W. Costerton
Author: Paul Stoodley ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×