Psychosis alters association between IQ and future risk of attempted suicide: cohort study of 1,109,475 Swedish men
Psychosis alters association between IQ and future risk of attempted suicide: cohort study of 1,109,475 Swedish men
Objectives: To explore associations between IQ measured in early adulthood and subsequent hospital admissions for attempted suicide and to explore the role of psychosis and examine associations of IQ with specific methods of attempted suicide.
Design: Cohort study.
Setting: Sweden.
Participants: 1 109 475 Swedish men with IQ measured in early adulthood followed up for an average 24 years.
Main outcome measures: Hospital admission for attempted suicide.
Results: 17 736 (1.6%) men had at least one hospital admission for attempted suicide by any means during follow-up. After adjustment for age and socioeconomic status, lower IQ scores were associated with an elevated risk of attempted suicide by any means (hazard ratio per standard deviation decrease in IQ=1.57, 95% confidence interval 1.54 to 1.60), with stepwise increases in risk across the full IQ range (P for trend<0.001). Similar associations were observed for all specific methods of attempted suicide. Separate analyses indicated that associations between IQ and attempted suicide were restricted to participants without psychosis and that IQ had no marked impact on risk of attempted suicide in those with psychosis.
Conclusions: Low IQ scores in early adulthood were associated with a subsequently increased risk of attempted suicide in men free from psychosis. A greater understanding of the mechanisms underlying these associations may provide opportunities and strategies for prevention.
Batty, G. David
605ce199-493d-4238-b9c8-a2c076672e83
Whitley, Elise
a61656e6-fdd9-4ff9-affc-661bb2960579
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Tynelius, Per
ac8bf45c-361b-4ae5-b4a1-234610c39cbd
Rasmussen, Finn
3ae452ae-94b8-4bd3-b54f-dd96518a8404
3 June 2010
Batty, G. David
605ce199-493d-4238-b9c8-a2c076672e83
Whitley, Elise
a61656e6-fdd9-4ff9-affc-661bb2960579
Deary, Ian J.
027158ae-fbfb-40ea-98b1-32d2690499ac
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Tynelius, Per
ac8bf45c-361b-4ae5-b4a1-234610c39cbd
Rasmussen, Finn
3ae452ae-94b8-4bd3-b54f-dd96518a8404
Batty, G. David, Whitley, Elise, Deary, Ian J., Gale, Catharine R., Tynelius, Per and Rasmussen, Finn
(2010)
Psychosis alters association between IQ and future risk of attempted suicide: cohort study of 1,109,475 Swedish men.
BMJ, 340 (7760), [c2506].
(doi:10.1136/bmj.c2506).
(PMID:20522657)
Abstract
Objectives: To explore associations between IQ measured in early adulthood and subsequent hospital admissions for attempted suicide and to explore the role of psychosis and examine associations of IQ with specific methods of attempted suicide.
Design: Cohort study.
Setting: Sweden.
Participants: 1 109 475 Swedish men with IQ measured in early adulthood followed up for an average 24 years.
Main outcome measures: Hospital admission for attempted suicide.
Results: 17 736 (1.6%) men had at least one hospital admission for attempted suicide by any means during follow-up. After adjustment for age and socioeconomic status, lower IQ scores were associated with an elevated risk of attempted suicide by any means (hazard ratio per standard deviation decrease in IQ=1.57, 95% confidence interval 1.54 to 1.60), with stepwise increases in risk across the full IQ range (P for trend<0.001). Similar associations were observed for all specific methods of attempted suicide. Separate analyses indicated that associations between IQ and attempted suicide were restricted to participants without psychosis and that IQ had no marked impact on risk of attempted suicide in those with psychosis.
Conclusions: Low IQ scores in early adulthood were associated with a subsequently increased risk of attempted suicide in men free from psychosis. A greater understanding of the mechanisms underlying these associations may provide opportunities and strategies for prevention.
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Published date: 3 June 2010
Organisations:
Medicine
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Local EPrints ID: 159693
URI: http://eprints.soton.ac.uk/id/eprint/159693
ISSN: 0959-8138
PURE UUID: e4b29a6b-885c-4790-8c6c-6043bfda9f25
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Date deposited: 06 Jul 2010 08:25
Last modified: 14 Mar 2024 02:38
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Author:
G. David Batty
Author:
Elise Whitley
Author:
Ian J. Deary
Author:
Per Tynelius
Author:
Finn Rasmussen
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