The University of Southampton
University of Southampton Institutional Repository

The impact of obesity on the course and outcome of acute pancreatitis

The impact of obesity on the course and outcome of acute pancreatitis
The impact of obesity on the course and outcome of acute pancreatitis
Obesity has reached epidemic proportions in many countries and is an established risk factor in many chronic illnesses, but its role in acute illness is less clear. Pancreatologists have long recognized obesity as a risk factor for a poor outcome in severe acute pancreatitis. There are now several studies that have identified obesity as a primary risk factor for developing local complications (abscess, pseudocyst, necrosis), organ failure, and death. Indeed, meta-analysis of these studies gives a relative risk of 4.3 for local complications, 2.0 for systemic complications, and 2.1 for death. This has led to proposed modifications of acute pancreatitis scoring systems to include obesity as an independent primary predictive factor of severe disease. Obesity is associated with a low-grade inflammatory state, which may predispose obese patients to such complications. Furthermore, visceral obesity and visceral adipose tissue may be particularly important in underlying the pathophysiology of these observations.
severe acute pancreatitis, obesity as a risk factor, complications
0960-8923
326-328
Abu Hilal, Mohammed
384e1c60-8519-4eed-8e92-91775aad4c47
Armstrong, Thomas
3b87df01-cd08-4048-91c4-7390c73a5960
Abu Hilal, Mohammed
384e1c60-8519-4eed-8e92-91775aad4c47
Armstrong, Thomas
3b87df01-cd08-4048-91c4-7390c73a5960

Abu Hilal, Mohammed and Armstrong, Thomas (2008) The impact of obesity on the course and outcome of acute pancreatitis. Obesity Surgery, 18 (3), 326-328. (doi:10.1007/s11695-007-9298-5). (PMID:18202895)

Record type: Article

Abstract

Obesity has reached epidemic proportions in many countries and is an established risk factor in many chronic illnesses, but its role in acute illness is less clear. Pancreatologists have long recognized obesity as a risk factor for a poor outcome in severe acute pancreatitis. There are now several studies that have identified obesity as a primary risk factor for developing local complications (abscess, pseudocyst, necrosis), organ failure, and death. Indeed, meta-analysis of these studies gives a relative risk of 4.3 for local complications, 2.0 for systemic complications, and 2.1 for death. This has led to proposed modifications of acute pancreatitis scoring systems to include obesity as an independent primary predictive factor of severe disease. Obesity is associated with a low-grade inflammatory state, which may predispose obese patients to such complications. Furthermore, visceral obesity and visceral adipose tissue may be particularly important in underlying the pathophysiology of these observations.

This record has no associated files available for download.

More information

Published date: March 2008
Keywords: severe acute pancreatitis, obesity as a risk factor, complications

Identifiers

Local EPrints ID: 172247
URI: http://eprints.soton.ac.uk/id/eprint/172247
ISSN: 0960-8923
PURE UUID: 9773f59e-579c-4fa0-9ab8-3f92915c4da8

Catalogue record

Date deposited: 25 Jan 2011 09:40
Last modified: 14 Mar 2024 02:28

Export record

Altmetrics

Contributors

Author: Mohammed Abu Hilal
Author: Thomas Armstrong

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×