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Sarcoidosis presenting with an acute Guillain-Barre syndrome

Sarcoidosis presenting with an acute Guillain-Barre syndrome
Sarcoidosis presenting with an acute Guillain-Barre syndrome
A 28 year old Caucasian male presented with an acute Guillain-Barré syndrome and bilateral facial weakness. He had an abnormal chest radiograph. Lumbar puncture revealed acellular fluid with a raised protein count and lung function tests showed a restrictive ventilatory defect. The patient deteriorated and required mechanical ventilation for 14 days. Steroids and plasmapheresis were not used and the patient spontaneously recovered. Two months after presentation limb power was almost normal but there was residual partial bilateral facial weakness. The chest radiograph remained abnormal and repeat lung function tests showed a persistent restrictive ventilatory defect and a reduced gas transfer coefficient. A transbronchial biopsy revealed non-caseating granulomata. The association between neurosarcoidosis and Guillain-Barré polyneuropathy is discussed and the literature reviewed.
0032-5473
765-767
Miller, R
7f200d8a-a05d-4e99-b0b3-e233c51594ee
Sheron, Nick
cbf852e3-cfaa-43b2-ab99-a954d96069f1
Semple, S
7018ff8c-5bab-4f7f-b557-2c14e4cb5fa1
Miller, R
7f200d8a-a05d-4e99-b0b3-e233c51594ee
Sheron, Nick
cbf852e3-cfaa-43b2-ab99-a954d96069f1
Semple, S
7018ff8c-5bab-4f7f-b557-2c14e4cb5fa1

Miller, R, Sheron, Nick and Semple, S (1989) Sarcoidosis presenting with an acute Guillain-Barre syndrome. Postgraduate Medical Journal, 65, 765-767. (doi:10.1136/pgmj.65.768.765). (PMID:2694139)

Record type: Article

Abstract

A 28 year old Caucasian male presented with an acute Guillain-Barré syndrome and bilateral facial weakness. He had an abnormal chest radiograph. Lumbar puncture revealed acellular fluid with a raised protein count and lung function tests showed a restrictive ventilatory defect. The patient deteriorated and required mechanical ventilation for 14 days. Steroids and plasmapheresis were not used and the patient spontaneously recovered. Two months after presentation limb power was almost normal but there was residual partial bilateral facial weakness. The chest radiograph remained abnormal and repeat lung function tests showed a persistent restrictive ventilatory defect and a reduced gas transfer coefficient. A transbronchial biopsy revealed non-caseating granulomata. The association between neurosarcoidosis and Guillain-Barré polyneuropathy is discussed and the literature reviewed.

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Published date: October 1989

Identifiers

Local EPrints ID: 172305
URI: http://eprints.soton.ac.uk/id/eprint/172305
ISSN: 0032-5473
PURE UUID: 0f0b31d3-6d04-4a97-9727-57293ca033ee
ORCID for Nick Sheron: ORCID iD orcid.org/0000-0001-5232-8292

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Date deposited: 25 Jan 2011 11:42
Last modified: 14 Mar 2024 02:28

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Contributors

Author: R Miller
Author: Nick Sheron ORCID iD
Author: S Semple

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