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Process optimization for the production of alginate microparticles containing wjmscs by a design of experiments (doe) approach

Process optimization for the production of alginate microparticles containing wjmscs by a design of experiments (doe) approach
Process optimization for the production of alginate microparticles containing wjmscs by a design of experiments (doe) approach

The paper describes (a) the isolation and characterization of Wharton's Jelly Mesenchymal Stem cells (WJMSCs), (b) the encapsulation of WJMSCs in alginate microbeads by an encapsulation device based on a vibrating-nozzle, (c) the optimization of the procedure for the encapsulation of WJMSCs by a Design of Experiment (DoE) approach, and (d) the evaluation of viability, proliferation and osteoblastic differentiation of the encapsulated WJMSCs.

0168-3659
e76-e77
Mazzitelli, S.
7ad66607-35de-4950-a089-ad8c53971a93
Capretto, L.
eef08c1d-b2bf-43f1-a310-39d7405a1f0b
Zhang, X.L.
d7cf1181-3276-4da1-9150-e212b333abb1
Penolazzi, L.
b16bb7cb-3277-48dd-851e-7b25661a6202
Lambertini, E.
8cd37ff5-428a-4fd0-bf61-82c52d6b380c
Piva, R.
acab6114-2ff1-4489-b2cd-b1f07379878b
Nastruzzi, C.
10305e34-5e70-461a-9703-deeab9985684
Mazzitelli, S.
7ad66607-35de-4950-a089-ad8c53971a93
Capretto, L.
eef08c1d-b2bf-43f1-a310-39d7405a1f0b
Zhang, X.L.
d7cf1181-3276-4da1-9150-e212b333abb1
Penolazzi, L.
b16bb7cb-3277-48dd-851e-7b25661a6202
Lambertini, E.
8cd37ff5-428a-4fd0-bf61-82c52d6b380c
Piva, R.
acab6114-2ff1-4489-b2cd-b1f07379878b
Nastruzzi, C.
10305e34-5e70-461a-9703-deeab9985684

Mazzitelli, S., Capretto, L., Zhang, X.L., Penolazzi, L., Lambertini, E., Piva, R. and Nastruzzi, C. (2010) Process optimization for the production of alginate microparticles containing wjmscs by a design of experiments (doe) approach. [in special issue: 11th European Sumposium on Controlled Drug Delivery] Journal of Controlled Release, 148 (1), e76-e77. (doi:10.1016/j.jconrel.2010.07.014).

Record type: Article

Abstract


The paper describes (a) the isolation and characterization of Wharton's Jelly Mesenchymal Stem cells (WJMSCs), (b) the encapsulation of WJMSCs in alginate microbeads by an encapsulation device based on a vibrating-nozzle, (c) the optimization of the procedure for the encapsulation of WJMSCs by a Design of Experiment (DoE) approach, and (d) the evaluation of viability, proliferation and osteoblastic differentiation of the encapsulated WJMSCs.

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Published date: 2010

Identifiers

Local EPrints ID: 172309
URI: http://eprints.soton.ac.uk/id/eprint/172309
ISSN: 0168-3659
PURE UUID: ea3d1fb6-9bea-48d7-a5ca-7a7d8a33fd37
ORCID for X.L. Zhang: ORCID iD orcid.org/0000-0002-4375-1571

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Date deposited: 25 Jan 2011 11:52
Last modified: 14 Mar 2024 02:52

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Contributors

Author: S. Mazzitelli
Author: L. Capretto
Author: X.L. Zhang ORCID iD
Author: L. Penolazzi
Author: E. Lambertini
Author: R. Piva
Author: C. Nastruzzi

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