Furosemide in the treatment of phosgene induced acute lung injury
Furosemide in the treatment of phosgene induced acute lung injury
Method: Using previously validated methods, 16 anaesthetised large white pigs were exposed to phosgene (target inhaled dose 0.3 mg kg(-1)), established on mechanical ventilation and randomised to treatment with either nebulised furosemide (4 ml of 10 mg x ml(-1) solution) or saline control. Treatments were given at 1, 3, 5, 7, 9, 12, 16 and 20 hours post phosgene exposure; the animals were monitored to 24 hours following phosgene exposure.
Results: Furosemide treatment had no effect on survival, and had a deleterious effect on PaO2: FiO2 ratio between 19 and 24 hours. All other measures investigated were unaffected by treatment.
Conclusion: Nebulised furosemide treatment following phosgene induced acute lung injury does not improve survival and worsens PaO2: FiO2 ratio. Nebulised furosemide should be avoided following phosgene exposure
245-250
Grainge, C.
ecdd36e0-55f8-4542-9e82-26e521106d8d
Smith, A.J.
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Jugg, B.J.
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Fairhall, S.J.
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Mann, T.
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Perrott, R.
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Jenner, J.
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Millar, T.M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Rice, P.
acd22f1e-c37f-4d23-805e-b7c86a949215
December 2010
Grainge, C.
ecdd36e0-55f8-4542-9e82-26e521106d8d
Smith, A.J.
ff8197a7-2583-4dae-a9d2-ad9d73a2f937
Jugg, B.J.
f0044f1b-8fb7-4d05-9a44-8cbf07317e14
Fairhall, S.J.
b7ba7fbf-1a9f-4dd9-a31b-ffee9ff5d482
Mann, T.
ac9f082a-8900-4041-a9e3-705d85e62466
Perrott, R.
8a8dbe5d-479f-4b02-9dfe-f8a258fa54ec
Jenner, J.
b52f8719-227b-4c06-b37c-8ff0b8881ba5
Millar, T.M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Rice, P.
acd22f1e-c37f-4d23-805e-b7c86a949215
Grainge, C., Smith, A.J., Jugg, B.J., Fairhall, S.J., Mann, T., Perrott, R., Jenner, J., Millar, T.M. and Rice, P.
(2010)
Furosemide in the treatment of phosgene induced acute lung injury.
Journal of the Royal Army Medical Corps, 156 (4), .
(PMID:21275359)
Abstract
Method: Using previously validated methods, 16 anaesthetised large white pigs were exposed to phosgene (target inhaled dose 0.3 mg kg(-1)), established on mechanical ventilation and randomised to treatment with either nebulised furosemide (4 ml of 10 mg x ml(-1) solution) or saline control. Treatments were given at 1, 3, 5, 7, 9, 12, 16 and 20 hours post phosgene exposure; the animals were monitored to 24 hours following phosgene exposure.
Results: Furosemide treatment had no effect on survival, and had a deleterious effect on PaO2: FiO2 ratio between 19 and 24 hours. All other measures investigated were unaffected by treatment.
Conclusion: Nebulised furosemide treatment following phosgene induced acute lung injury does not improve survival and worsens PaO2: FiO2 ratio. Nebulised furosemide should be avoided following phosgene exposure
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Published date: December 2010
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Local EPrints ID: 178475
URI: http://eprints.soton.ac.uk/id/eprint/178475
ISSN: 0035-8665
PURE UUID: 576032e0-7736-4f07-a743-1f937cc4a35f
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Date deposited: 24 Mar 2011 16:04
Last modified: 08 Jan 2022 03:05
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Contributors
Author:
C. Grainge
Author:
A.J. Smith
Author:
B.J. Jugg
Author:
S.J. Fairhall
Author:
T. Mann
Author:
R. Perrott
Author:
J. Jenner
Author:
T.M. Millar
Author:
P. Rice
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