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Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes

Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes
Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes
Environmental and age-related effects on learning and memory were analysed and compared with changes observed in astrocyte laminar distribution in the dentate gyrus. Aged (20 months) and young (6 months) adult female albino Swiss mice were housed from weaning either in impoverished conditions or in enriched conditions, and tested for episodic-like and water maze spatial memories. After these behavioral tests, brain hippocampal sections were immunolabeled for glial fibrillary acid protein to identify astrocytes. The effects of environmental enrichment on episodic-like memory were not dependent on age, and may protect water maze spatial learning and memory from declines induced by aging or impoverished environment. In the dentate gyrus, the number of astrocytes increased with both aging and enriched environment in the molecular layer, increased only with aging in the polymorphic layer, and was unchanged in the granular layer. We suggest that long-term experience-induced glial plasticity by enriched environment may represent at least part of the circuitry groundwork for improvements in behavioral performance in the aged mice brain
0953-816X
509-519
Diniz, Daniel G.
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Foro, César A. R.
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Rego, Carla M. D.
b184e7bb-7c4c-4f85-bc7a-fbbd9faa5046
Gloria, David A.
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De Oliveira, Fabio R. R.
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Paes, Juliana M. P.
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De Sousa, Aline A.
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Tokuhashi, Tatyana P.
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Trindade, Lucas S.
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Turiel, Maíra C. P.
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Vasconcelos, Erick G. R.
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Torres, João B.
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Cunnigham, Colm
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Perry, Victor Hugh
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Da Costa Vasconcelos, Pedro F.
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Diniz, Cristovam W. P.
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Diniz, Daniel G.
e4935dd7-54c5-4d3e-975e-7930b5820fb1
Foro, César A. R.
50c13c88-2b1c-4975-9d98-01bd78a71dcd
Rego, Carla M. D.
b184e7bb-7c4c-4f85-bc7a-fbbd9faa5046
Gloria, David A.
6e511f63-17e3-42f9-a8a7-968ded4606a3
De Oliveira, Fabio R. R.
dac5df1d-11f3-4d3f-86a8-ba5bec8ed2c7
Paes, Juliana M. P.
d0a94fe4-fe19-4a91-9525-6684b9295cab
De Sousa, Aline A.
9c330161-d3ed-4a7b-bad3-a4df8e88eb25
Tokuhashi, Tatyana P.
78ead85f-174a-49fd-9033-33b4ae4c693a
Trindade, Lucas S.
b38d6cda-6ff7-4806-b51c-2a30468c9612
Turiel, Maíra C. P.
88e62abc-9a98-4c9c-9f5e-0c3655c8bdf6
Vasconcelos, Erick G. R.
5b44379e-63d4-487f-a5a4-a8422df9f968
Torres, João B.
cfaa687b-3855-4de7-8dd7-ec85e16698ab
Cunnigham, Colm
1d42d6d5-91df-4e91-bbb6-5a7559079219
Perry, Victor Hugh
8f29d36a-8e1f-4082-8700-09483bbaeae4
Da Costa Vasconcelos, Pedro F.
4c996ece-f6f8-430c-a6be-5576f814d2e5
Diniz, Cristovam W. P.
fc584ab6-86d7-4ad8-90f3-7b98d1ef77cd

Diniz, Daniel G., Foro, César A. R., Rego, Carla M. D., Gloria, David A., De Oliveira, Fabio R. R., Paes, Juliana M. P., De Sousa, Aline A., Tokuhashi, Tatyana P., Trindade, Lucas S., Turiel, Maíra C. P., Vasconcelos, Erick G. R., Torres, João B., Cunnigham, Colm, Perry, Victor Hugh, Da Costa Vasconcelos, Pedro F. and Diniz, Cristovam W. P. (2010) Environmental impoverishment and aging alter object recognition, spatial learning, and dentate gyrus astrocytes. European Journal of Neuroscience, 32 (3), 509-519. (doi:10.1111/j.1460-9568.2010.07296.x). (PMID:20704596)

Record type: Article

Abstract

Environmental and age-related effects on learning and memory were analysed and compared with changes observed in astrocyte laminar distribution in the dentate gyrus. Aged (20 months) and young (6 months) adult female albino Swiss mice were housed from weaning either in impoverished conditions or in enriched conditions, and tested for episodic-like and water maze spatial memories. After these behavioral tests, brain hippocampal sections were immunolabeled for glial fibrillary acid protein to identify astrocytes. The effects of environmental enrichment on episodic-like memory were not dependent on age, and may protect water maze spatial learning and memory from declines induced by aging or impoverished environment. In the dentate gyrus, the number of astrocytes increased with both aging and enriched environment in the molecular layer, increased only with aging in the polymorphic layer, and was unchanged in the granular layer. We suggest that long-term experience-induced glial plasticity by enriched environment may represent at least part of the circuitry groundwork for improvements in behavioral performance in the aged mice brain

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Published date: August 2010

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Local EPrints ID: 180195
URI: http://eprints.soton.ac.uk/id/eprint/180195
ISSN: 0953-816X
PURE UUID: 66206137-1fe1-4b2d-a834-046290591cd5

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Date deposited: 06 Apr 2011 08:20
Last modified: 14 Mar 2024 02:51

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Contributors

Author: Daniel G. Diniz
Author: César A. R. Foro
Author: Carla M. D. Rego
Author: David A. Gloria
Author: Fabio R. R. De Oliveira
Author: Juliana M. P. Paes
Author: Aline A. De Sousa
Author: Tatyana P. Tokuhashi
Author: Lucas S. Trindade
Author: Maíra C. P. Turiel
Author: Erick G. R. Vasconcelos
Author: João B. Torres
Author: Colm Cunnigham
Author: Pedro F. Da Costa Vasconcelos
Author: Cristovam W. P. Diniz

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