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Simulation of the regional manifestation of asthma

Simulation of the regional manifestation of asthma
Simulation of the regional manifestation of asthma
Asthma presents serious medical problems of global proportions. Clinical data suggest that the disease occurs preferentially at regions designated by large (0 </= I </= 5), central (6 </= I </= 11), and small (12 </= I </= 16) airways, where I defines branching generations within lungs. Our straightforward hypothesis, therefore, was that the efficacies of pharmacologic drugs proposed for the treatment and prophylaxis of asthma would be enhanced via their targeted delivery to appropriate sites. Hence, we have developed a mathematical model describing the behavior and fate of inhaled aerosols. Original algorithms have been derived to detail the physical manifestation of asthma as distinct components of smooth muscle constriction and inflammation. We have conducted a systematic analysis of the relative effects of morphology, ventilation, and particle size on aerosol deposition. Different intensities of asthma were simulated by reducing airway diameters by prescribed amounts. To show the real clinical applications of modeling, we have also simulated the performance of a popular nebulizer. Regarding therapeutic implications, it is clear that disease-induced changes in airway morphologies have pronounced effects on the administration of inhaled drugs. Likewise, ventilation affects both the total aerosol mass deposited and its relative spatial distribution among airways. By formulating these effects, the computer code allows drugs (e.g., bronchodilators for constriction, steroids for inflammation) to be selectively deposited. We suggest, therefore, that the code can be used in a complementary manner with clinical studies and can be integrated into aerosol therapy regimens.
aerosols, algorithms, anatomy and histology, article, asthma, body fluids, computer simulation, disease, drug delivery systems, drug therapy, humans, imaging three-dimensional, lung, metabolism, methods, models anatomic, models biological, nebulizers and vaporizers, physiology, research, therapy, trends, mathematical modeling, drug delivery, disease simulations
0022-3549
1205 - 1216
Sbirlea-Apiou, Gabriela
9f1e2ddf-9d53-4522-b79b-2f5c34fd4024
Lemaire, Marc
8118de43-0cf5-4dfe-abca-df428d7d1dce
Katz, Ira
249570b4-914e-44b7-9515-896a827dbb77
Conway, Joy
bbe9a2e4-fb85-4d4a-a38c-0c1832c32d06
Fleming, John
9dfe6059-3383-4621-9ef4-4ea221640b55
Martonen, Ted
8ad9a29d-d529-4001-9f7a-b1ced16d447e
Sbirlea-Apiou, Gabriela
9f1e2ddf-9d53-4522-b79b-2f5c34fd4024
Lemaire, Marc
8118de43-0cf5-4dfe-abca-df428d7d1dce
Katz, Ira
249570b4-914e-44b7-9515-896a827dbb77
Conway, Joy
bbe9a2e4-fb85-4d4a-a38c-0c1832c32d06
Fleming, John
9dfe6059-3383-4621-9ef4-4ea221640b55
Martonen, Ted
8ad9a29d-d529-4001-9f7a-b1ced16d447e

Sbirlea-Apiou, Gabriela, Lemaire, Marc, Katz, Ira, Conway, Joy, Fleming, John and Martonen, Ted (2004) Simulation of the regional manifestation of asthma. Journal of Pharmaceutical Sciences, 93 (5), 1205 - 1216. (doi:10.1002/jps.20029).

Record type: Article

Abstract

Asthma presents serious medical problems of global proportions. Clinical data suggest that the disease occurs preferentially at regions designated by large (0 </= I </= 5), central (6 </= I </= 11), and small (12 </= I </= 16) airways, where I defines branching generations within lungs. Our straightforward hypothesis, therefore, was that the efficacies of pharmacologic drugs proposed for the treatment and prophylaxis of asthma would be enhanced via their targeted delivery to appropriate sites. Hence, we have developed a mathematical model describing the behavior and fate of inhaled aerosols. Original algorithms have been derived to detail the physical manifestation of asthma as distinct components of smooth muscle constriction and inflammation. We have conducted a systematic analysis of the relative effects of morphology, ventilation, and particle size on aerosol deposition. Different intensities of asthma were simulated by reducing airway diameters by prescribed amounts. To show the real clinical applications of modeling, we have also simulated the performance of a popular nebulizer. Regarding therapeutic implications, it is clear that disease-induced changes in airway morphologies have pronounced effects on the administration of inhaled drugs. Likewise, ventilation affects both the total aerosol mass deposited and its relative spatial distribution among airways. By formulating these effects, the computer code allows drugs (e.g., bronchodilators for constriction, steroids for inflammation) to be selectively deposited. We suggest, therefore, that the code can be used in a complementary manner with clinical studies and can be integrated into aerosol therapy regimens.

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More information

Published date: 2004
Keywords: aerosols, algorithms, anatomy and histology, article, asthma, body fluids, computer simulation, disease, drug delivery systems, drug therapy, humans, imaging three-dimensional, lung, metabolism, methods, models anatomic, models biological, nebulizers and vaporizers, physiology, research, therapy, trends, mathematical modeling, drug delivery, disease simulations

Identifiers

Local EPrints ID: 18029
URI: http://eprints.soton.ac.uk/id/eprint/18029
ISSN: 0022-3549
PURE UUID: dc2fa920-814a-4f44-8a88-91287729e469
ORCID for Joy Conway: ORCID iD orcid.org/0000-0001-6464-1526

Catalogue record

Date deposited: 23 Nov 2005
Last modified: 15 Mar 2024 06:02

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Contributors

Author: Gabriela Sbirlea-Apiou
Author: Marc Lemaire
Author: Ira Katz
Author: Joy Conway ORCID iD
Author: John Fleming
Author: Ted Martonen

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