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Long term follow-up of a randomised controlled trial of services for urinary symptoms

Long term follow-up of a randomised controlled trial of services for urinary symptoms
Long term follow-up of a randomised controlled trial of services for urinary symptoms
Background: Given the extent and priority of urinary symptoms there is little evidence available to inform service provision in relation to the long term effects of interventions. This study aims to determine the long term (6 year) clinical effectiveness and costs of a new continence nurse led service compared to standard care for urinary symptoms.

Methods: A long term follow-up study of a 2-arm, non-blinded randomised controlled trial that recruited from a community based population between 1998-2000 in Leicestershire and Rutland UK was undertaken. 3746 men and women aged 40 years and over were followed up from the original trial. The continence nurse practitioner (CNP) intervention comprised a continence service provided by specially trained nurses delivering evidence-based interventions using pre-determined care pathways. The standard care (SC) arm comprised access to existing primary care including General Practitioner and continence advisory services in the area. Primary outcome: Improvement in one or more symptom. Secondary outcomes included: a) Leicester Impact scale; b) patient perception of problem; c) number of symptoms alleviated and cost-effectiveness; all were recorded at long term follow-up (average 6 years) post-randomisation.

Results: Overall at long-term follow-up (average 6 years) significantly more individuals in the CNP group (72%) had improved (i.e had fewer symptoms) compared to those in the SC group (67%) (difference of 5% 95% (CI = 0.6 to 9;p = 0.02)).

Conclusion: The differences in outcome between the two randomised groups shown immediately post treatment had decreased by half in terms of symptom improvement at long term follow-up. Although the difference was statistically significant, the clinical significance may not be, although the direction of the difference favoured the new CNP service.

1472-6963
Williams, Kate S.
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Coleby, Dawn
920054e5-6a24-4427-99e6-7a770902ee3b
Abrams, Keith R.
6db24e9a-24bb-4f34-8d32-a97352af4e09
Turner, David A.
9a226386-4d55-4bb2-a6e9-a5e6ab6d2f9b
Shaw, Christine
9e13775b-6a02-499c-bdfd-b983666a34d0
Assassa, R. Phillip
aae20e38-b337-4182-8ee0-d20202ebeca9
Cooper, Nicola J.
31b6f28b-a62c-4715-878a-9db9e86535e2
Donaldson, Madeleine M.K.
c85150d0-a46e-4b16-8300-cb57632a24f7
McGrother, Catherine W.
3526cb81-d468-40e5-ab6c-b1e21bd48719
Williams, Kate S.
8a9aa445-b636-413c-9b1e-7d618778decf
Coleby, Dawn
920054e5-6a24-4427-99e6-7a770902ee3b
Abrams, Keith R.
6db24e9a-24bb-4f34-8d32-a97352af4e09
Turner, David A.
9a226386-4d55-4bb2-a6e9-a5e6ab6d2f9b
Shaw, Christine
9e13775b-6a02-499c-bdfd-b983666a34d0
Assassa, R. Phillip
aae20e38-b337-4182-8ee0-d20202ebeca9
Cooper, Nicola J.
31b6f28b-a62c-4715-878a-9db9e86535e2
Donaldson, Madeleine M.K.
c85150d0-a46e-4b16-8300-cb57632a24f7
McGrother, Catherine W.
3526cb81-d468-40e5-ab6c-b1e21bd48719

Williams, Kate S., Coleby, Dawn, Abrams, Keith R., Turner, David A., Shaw, Christine, Assassa, R. Phillip, Cooper, Nicola J., Donaldson, Madeleine M.K. and McGrother, Catherine W. (2011) Long term follow-up of a randomised controlled trial of services for urinary symptoms. BMC Health Services Research, 11 (58). (doi:10.1186/1472-6963-11-58). (PMID:21401941)

Record type: Article

Abstract

Background: Given the extent and priority of urinary symptoms there is little evidence available to inform service provision in relation to the long term effects of interventions. This study aims to determine the long term (6 year) clinical effectiveness and costs of a new continence nurse led service compared to standard care for urinary symptoms.

Methods: A long term follow-up study of a 2-arm, non-blinded randomised controlled trial that recruited from a community based population between 1998-2000 in Leicestershire and Rutland UK was undertaken. 3746 men and women aged 40 years and over were followed up from the original trial. The continence nurse practitioner (CNP) intervention comprised a continence service provided by specially trained nurses delivering evidence-based interventions using pre-determined care pathways. The standard care (SC) arm comprised access to existing primary care including General Practitioner and continence advisory services in the area. Primary outcome: Improvement in one or more symptom. Secondary outcomes included: a) Leicester Impact scale; b) patient perception of problem; c) number of symptoms alleviated and cost-effectiveness; all were recorded at long term follow-up (average 6 years) post-randomisation.

Results: Overall at long-term follow-up (average 6 years) significantly more individuals in the CNP group (72%) had improved (i.e had fewer symptoms) compared to those in the SC group (67%) (difference of 5% 95% (CI = 0.6 to 9;p = 0.02)).

Conclusion: The differences in outcome between the two randomised groups shown immediately post treatment had decreased by half in terms of symptom improvement at long term follow-up. Although the difference was statistically significant, the clinical significance may not be, although the direction of the difference favoured the new CNP service.

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More information

Published date: March 2011
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 181275
URI: http://eprints.soton.ac.uk/id/eprint/181275
ISSN: 1472-6963
PURE UUID: a3d666e3-056a-478b-bfb6-25f36602fb3b

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Date deposited: 14 Apr 2011 11:51
Last modified: 14 Mar 2024 02:55

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Contributors

Author: Kate S. Williams
Author: Dawn Coleby
Author: Keith R. Abrams
Author: David A. Turner
Author: Christine Shaw
Author: R. Phillip Assassa
Author: Nicola J. Cooper
Author: Madeleine M.K. Donaldson
Author: Catherine W. McGrother

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