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Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema

Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema
Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema
These data would support a model where barrier dysfunction possibly promotes greater allergen penetration and delivery to drive allergen-specific CD4+ T cells. This could further contribute to respiratory and cutaneous inflammatory disease.
0007-0963
544-549
McPherson, T.
c38a2d1d-b223-4c1a-9ebe-6b59c6761d51
Sherman, V. J.
1e3a8d96-a866-49f2-9276-d6c4a3dffac6
Aslam, A.
62b28fb0-b42e-4a71-ae26-bc0f6a606e9a
Crack, L.
a973517f-b34d-42c8-a9c6-f44d83775e85
Chan, H.
22d504e0-18e2-4d44-b81b-e3ea5fdea03a
Lloyd-Lavery, A.
cf6cbd57-ea1c-4179-9288-a1ce609a3d02
Jones, L.E.
0a801680-fecd-400f-a771-b0ac1fcd02c6
Ardern-Jones, M
7ac43c24-94ab-4d19-ba69-afaa546bec90
Ogg, G.
e675c1bb-5b5e-4317-9887-e9f377220d0d
McPherson, T.
c38a2d1d-b223-4c1a-9ebe-6b59c6761d51
Sherman, V. J.
1e3a8d96-a866-49f2-9276-d6c4a3dffac6
Aslam, A.
62b28fb0-b42e-4a71-ae26-bc0f6a606e9a
Crack, L.
a973517f-b34d-42c8-a9c6-f44d83775e85
Chan, H.
22d504e0-18e2-4d44-b81b-e3ea5fdea03a
Lloyd-Lavery, A.
cf6cbd57-ea1c-4179-9288-a1ce609a3d02
Jones, L.E.
0a801680-fecd-400f-a771-b0ac1fcd02c6
Ardern-Jones, M
7ac43c24-94ab-4d19-ba69-afaa546bec90
Ogg, G.
e675c1bb-5b5e-4317-9887-e9f377220d0d

McPherson, T., Sherman, V. J., Aslam, A., Crack, L., Chan, H., Lloyd-Lavery, A., Jones, L.E., Ardern-Jones, M and Ogg, G. (2010) Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema. British Journal of Dermatology, 163 (3), 544-549. (doi:10.1111/j.1365-2133.2010.09866.x). (PMID:20500796)

Record type: Article

Abstract

These data would support a model where barrier dysfunction possibly promotes greater allergen penetration and delivery to drive allergen-specific CD4+ T cells. This could further contribute to respiratory and cutaneous inflammatory disease.

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Published date: September 2010

Identifiers

Local EPrints ID: 181625
URI: http://eprints.soton.ac.uk/id/eprint/181625
ISSN: 0007-0963
PURE UUID: ecd7dbdb-9f54-47d7-a55b-05d7be134cb4
ORCID for M Ardern-Jones: ORCID iD orcid.org/0000-0003-1466-2016

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Date deposited: 15 Apr 2011 11:12
Last modified: 15 Mar 2024 03:28

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Contributors

Author: T. McPherson
Author: V. J. Sherman
Author: A. Aslam
Author: L. Crack
Author: H. Chan
Author: A. Lloyd-Lavery
Author: L.E. Jones
Author: M Ardern-Jones ORCID iD
Author: G. Ogg

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