Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins
Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins
Stimulation of osteogenesis in human bone marrow stromal cells by surface attachment and endocytosis of arginine-functionalized hydroxyapatite nanoparticles is enhanced when serum proteins are omitted from the culture medium for an initial 24 hour period. This effect, which is related to nanoparticle binding of the serum proteins, could be an important consideration in nanoparticle-induced bioactivity and nanotoxicity in general.
osteogenic nanoparticles, nanoparticle-induced bioactivity, skeletal repair, protein adsorption
1986-1991
Hails, Lauren A.
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Babister, Jodie C.
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Inglis, Stefanie
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Davis, Sean A.
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Oreffo, Richard O.
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Mann, Stephan
eba3623e-46ed-4b41-b52a-61ce5d4c6063
September 2010
Hails, Lauren A.
0db2a3de-0599-4a1d-89b6-5415544612f5
Babister, Jodie C.
3b35e463-b623-403c-91c3-88a590cea674
Inglis, Stefanie
cb950bb9-8b89-41c0-b547-3206580d16b4
Davis, Sean A.
b4bf65bc-72be-437f-a711-d6dafad5f3d1
Oreffo, Richard O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Mann, Stephan
eba3623e-46ed-4b41-b52a-61ce5d4c6063
Hails, Lauren A., Babister, Jodie C., Inglis, Stefanie, Davis, Sean A., Oreffo, Richard O. and Mann, Stephan
(2010)
Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins.
Small, 6 (18), .
(doi:10.1002/smll.201000939).
(PMID:20721953)
Abstract
Stimulation of osteogenesis in human bone marrow stromal cells by surface attachment and endocytosis of arginine-functionalized hydroxyapatite nanoparticles is enhanced when serum proteins are omitted from the culture medium for an initial 24 hour period. This effect, which is related to nanoparticle binding of the serum proteins, could be an important consideration in nanoparticle-induced bioactivity and nanotoxicity in general.
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Published date: September 2010
Keywords:
osteogenic nanoparticles, nanoparticle-induced bioactivity, skeletal repair, protein adsorption
Identifiers
Local EPrints ID: 181651
URI: http://eprints.soton.ac.uk/id/eprint/181651
ISSN: 1613-6810
PURE UUID: 12f3bf1a-f83b-4260-9a6d-6bee2a12ac98
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Date deposited: 18 Apr 2011 14:45
Last modified: 15 Mar 2024 03:03
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Contributors
Author:
Lauren A. Hails
Author:
Jodie C. Babister
Author:
Stefanie Inglis
Author:
Sean A. Davis
Author:
Stephan Mann
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