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The impact of genetic testing for Crohn's disease, risk magnitude and graphical format on motivation to stop smoking: an experimental analogue study

The impact of genetic testing for Crohn's disease, risk magnitude and graphical format on motivation to stop smoking: an experimental analogue study
The impact of genetic testing for Crohn's disease, risk magnitude and graphical format on motivation to stop smoking: an experimental analogue study
Genetic tests may motivate risk-reducing behaviour more than other types of tests because they generate higher risk magnitudes and because their results have high personal relevance. To date, trial designs have not allowed the disentangling of the effects of these two factors. This analogue study examines the independent impacts of risk magnitude and provenance, and of risk display type, on motivation to quit smoking. A total of 180 smokers were randomly allocated to one of the 18 Crohn's disease risk vignettes in a 3 (risk provenance: family history. genetic test mutation positive. genetic test mutation negative) × 3 (risk magnitude: 3%, 6%, 50%) × 2 (display: grouped or dispersed icons) design. The 50% group had significantly higher intentions to quit than the 3% group. A significant risk provenance × magnitude interaction showed that participants in 50% or 6% groups were equally motivated, regardless of risk provenance, while participants in the 3% group had higher intentions associated with a mutation negative result than with a result based on family history alone. Grouped icon displays were more motivating than the dispersed icons. Using genetic tests to estimate risks of common complex conditions may not motivate behaviour change beyond the impact of the numerical risk estimates derived from such tests.
communication, Crohn's disease, genetic testing, motivation, risk, smoking cessation
0009-9163
306-314
Wright, A.J.
d9e723cc-c279-459a-88d0-1453aafc5227
Takeichi, C.
2cc4eb0b-a56b-456e-80ed-71fbf0a602cc
Whitwell, S.C.L.
bcfec664-26b6-400f-a5ce-7b5dd700e057
Hankins, M.
ce4b7d68-3320-4af4-9dd7-3537a4b07219
Marteaua, T.M.
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Wright, A.J.
d9e723cc-c279-459a-88d0-1453aafc5227
Takeichi, C.
2cc4eb0b-a56b-456e-80ed-71fbf0a602cc
Whitwell, S.C.L.
bcfec664-26b6-400f-a5ce-7b5dd700e057
Hankins, M.
ce4b7d68-3320-4af4-9dd7-3537a4b07219
Marteaua, T.M.
8f313cba-3f7d-4e0e-b483-03dc6e77d89c

Wright, A.J., Takeichi, C., Whitwell, S.C.L., Hankins, M. and Marteaua, T.M. (2008) The impact of genetic testing for Crohn's disease, risk magnitude and graphical format on motivation to stop smoking: an experimental analogue study. Clinical Genetics, 73 (4), 306-314. (doi:10.1111/j.1399-0004.2008.00964.x).

Record type: Article

Abstract

Genetic tests may motivate risk-reducing behaviour more than other types of tests because they generate higher risk magnitudes and because their results have high personal relevance. To date, trial designs have not allowed the disentangling of the effects of these two factors. This analogue study examines the independent impacts of risk magnitude and provenance, and of risk display type, on motivation to quit smoking. A total of 180 smokers were randomly allocated to one of the 18 Crohn's disease risk vignettes in a 3 (risk provenance: family history. genetic test mutation positive. genetic test mutation negative) × 3 (risk magnitude: 3%, 6%, 50%) × 2 (display: grouped or dispersed icons) design. The 50% group had significantly higher intentions to quit than the 3% group. A significant risk provenance × magnitude interaction showed that participants in 50% or 6% groups were equally motivated, regardless of risk provenance, while participants in the 3% group had higher intentions associated with a mutation negative result than with a result based on family history alone. Grouped icon displays were more motivating than the dispersed icons. Using genetic tests to estimate risks of common complex conditions may not motivate behaviour change beyond the impact of the numerical risk estimates derived from such tests.

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Published date: April 2008
Keywords: communication, Crohn's disease, genetic testing, motivation, risk, smoking cessation

Identifiers

Local EPrints ID: 187371
URI: http://eprints.soton.ac.uk/id/eprint/187371
ISSN: 0009-9163
PURE UUID: a918b9e4-127c-481e-9b35-1c0d15fd9564

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Date deposited: 17 May 2011 14:36
Last modified: 14 Mar 2024 03:24

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Contributors

Author: A.J. Wright
Author: C. Takeichi
Author: S.C.L. Whitwell
Author: M. Hankins
Author: T.M. Marteaua

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