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Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound

Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound
Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound
Objectives. To investigate the effect of gestational age at birth on the frequency of ultrasound-detected brain lesions in infants born at <33 weeks of gestation and to investigate whether the relationship between neonatal cranial ultrasound diagnosis and neurodevelopmental outcome at 8 years of age was independent of gestational age.

Methods. Eight hundred forty-seven infants born at <33 weeks of gestation, admitted to a single tertiary referral center between 1983 and 1988, underwent serial neonatal cranial ultrasound. At 8 years of age neurodevelopmental outcome was assessed by structured neurologic examination, psychometric tests (Wechsler Intelligence Scale for Children), tests of visuomotor integration (Beery) and motor impairment (Henderson-Stott). Infants were subdivided into a group born at <28 weeks and a group born at between 28 and 32 weeks. Neurodevelopmental outcome was analyzed for each ultrasound diagnosis.

Results. Hemorrhagic lesions such as germinal matrix/intraventricular hemorrhage and hemorrhagic parenchymal infarction were more frequent in infants born at <28 weeks. There was no difference in the frequency of cystic periventricular leucomalacia between the 2 groups. When neurodevelopmental outcome for each ultrasound diagnosis was compared, no significant difference was found between the 2 gestational age groups.

Conclusion. In the gestational age range studied, adverse neurodevelopmental outcome depends primarily on the type of the intracranial lesion rather than on gestational age.
0031-4005
1108-1114
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Roth, Simon
5de63212-d239-4638-8015-95e2a6496181
Baudin, Jenny
3790a784-0e19-483d-a187-b25079ddeaad
Stewart, Ann L.
f4768a23-ad9d-414c-95ec-5efe2234b794
Neville, Brian G. R.
7d4a7d56-e223-4cf4-8e8b-c1be5ddce55b
Wyatt, John S.
e0f73250-efa3-4bb6-adf6-ab0c92432ccb
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Roth, Simon
5de63212-d239-4638-8015-95e2a6496181
Baudin, Jenny
3790a784-0e19-483d-a187-b25079ddeaad
Stewart, Ann L.
f4768a23-ad9d-414c-95ec-5efe2234b794
Neville, Brian G. R.
7d4a7d56-e223-4cf4-8e8b-c1be5ddce55b
Wyatt, John S.
e0f73250-efa3-4bb6-adf6-ab0c92432ccb

Vollmer, Brigitte, Roth, Simon, Baudin, Jenny, Stewart, Ann L., Neville, Brian G. R. and Wyatt, John S. (2003) Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound. Pediatrics, 112 (5), 1108-1114. (doi:10.1542/peds.112.5.1108). (PMID:14595054)

Record type: Article

Abstract

Objectives. To investigate the effect of gestational age at birth on the frequency of ultrasound-detected brain lesions in infants born at <33 weeks of gestation and to investigate whether the relationship between neonatal cranial ultrasound diagnosis and neurodevelopmental outcome at 8 years of age was independent of gestational age.

Methods. Eight hundred forty-seven infants born at <33 weeks of gestation, admitted to a single tertiary referral center between 1983 and 1988, underwent serial neonatal cranial ultrasound. At 8 years of age neurodevelopmental outcome was assessed by structured neurologic examination, psychometric tests (Wechsler Intelligence Scale for Children), tests of visuomotor integration (Beery) and motor impairment (Henderson-Stott). Infants were subdivided into a group born at <28 weeks and a group born at between 28 and 32 weeks. Neurodevelopmental outcome was analyzed for each ultrasound diagnosis.

Results. Hemorrhagic lesions such as germinal matrix/intraventricular hemorrhage and hemorrhagic parenchymal infarction were more frequent in infants born at <28 weeks. There was no difference in the frequency of cystic periventricular leucomalacia between the 2 groups. When neurodevelopmental outcome for each ultrasound diagnosis was compared, no significant difference was found between the 2 gestational age groups.

Conclusion. In the gestational age range studied, adverse neurodevelopmental outcome depends primarily on the type of the intracranial lesion rather than on gestational age.

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More information

Published date: 1 November 2003

Identifiers

Local EPrints ID: 189523
URI: http://eprints.soton.ac.uk/id/eprint/189523
ISSN: 0031-4005
PURE UUID: 319c21a1-28b1-4e6d-8fc2-559dc7de42f9
ORCID for Brigitte Vollmer: ORCID iD orcid.org/0000-0003-4088-5336

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Date deposited: 02 Jun 2011 14:38
Last modified: 15 Mar 2024 03:36

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Contributors

Author: Simon Roth
Author: Jenny Baudin
Author: Ann L. Stewart
Author: Brian G. R. Neville
Author: John S. Wyatt

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