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The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma

The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma
The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma
The present study was designed to observe the effects of 8 wk of treatment with formoterol (Foradil) 24 microgram, budesonide 400 microgram, and matched placebo inhaled twice a day on inflammatory indices in the bronchial mucosa of 64 patients with mild atopic asthma. Biopsies were obtained at the start and 1 wk before stopping a 9-wk period of treatment, and inflammatory cell numbers were assessed in the submucosa and epithelium by immunohistochemistry. Regular formoterol significantly reduced the number of submucosal mast cells, with a similar trend for eosinophils but not activated T cells. A subgroup analysis conducted in biopsies with >= 10 eosinophils per mm2 revealed a significant reduction in eosinophil numbers when compared with both pretreatment baseline (p < 0.01) and changes after placebo (p < 0.01). Parallel, but less pronounced, effects were observed on mast cell but not on CD25(+) T cell numbers. There was no effect of any of the three treatments on BAL levels of mast cell or eosinophil mediators. We conclude that regular treatment with inhaled formoterol reduces rather than increases inflammatory cells in the mucosa of asthmatic patients. It is possible that these cellular effects of formoterol may contribute to the therapeutic efficacy of this drug when used regularly in the treatment
1073-449X
79-86
Wallin, Annika
113ea341-ee86-42ed-9afc-8a60d75e8924
Sandström, Thomas
77a4c11d-a84f-4a52-9bfe-4ec83f62363a
Söderberg, Margaetha
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Howarth, Peter H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Lundbäck, Bo
eb226874-21a7-4d1f-bd27-a29d83eabb02
Della-Cioppa, Giovanni
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Wilson, Susan J.
21c6875d-6870-441b-ae7a-603562a646b8
Judd, Mary
9ee50e4d-7a74-4b1c-9a7c-98f29e301eed
Djukanović, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Holgate, Stephen T.
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Lindberg, Anne
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Larssen, Lars
aff60158-fcd7-4125-8266-4cf70215afa8
Melander, Bo
cc09bd52-0d8f-4e96-9579-240ba7c32f53
Wallin, Annika
113ea341-ee86-42ed-9afc-8a60d75e8924
Sandström, Thomas
77a4c11d-a84f-4a52-9bfe-4ec83f62363a
Söderberg, Margaetha
4f2aa46a-2334-4112-8d1a-ccd24a956dc0
Howarth, Peter H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Lundbäck, Bo
eb226874-21a7-4d1f-bd27-a29d83eabb02
Della-Cioppa, Giovanni
20d75b80-a2dc-46e2-8735-4bf2db73bfed
Wilson, Susan J.
21c6875d-6870-441b-ae7a-603562a646b8
Judd, Mary
9ee50e4d-7a74-4b1c-9a7c-98f29e301eed
Djukanović, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Lindberg, Anne
9bfc794b-98bb-48e1-8d06-55024eed58e3
Larssen, Lars
aff60158-fcd7-4125-8266-4cf70215afa8
Melander, Bo
cc09bd52-0d8f-4e96-9579-240ba7c32f53

Wallin, Annika, Sandström, Thomas, Söderberg, Margaetha, Howarth, Peter H., Lundbäck, Bo, Della-Cioppa, Giovanni, Wilson, Susan J., Judd, Mary, Djukanović, Ratko, Holgate, Stephen T., Lindberg, Anne, Larssen, Lars and Melander, Bo (1999) The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma. American Journal of Respiratory and Critical Care Medicine, 159 (1), 79-86. (doi:10.1164/ajrccm.159.1.9801007). (PMID:9872822)

Record type: Article

Abstract

The present study was designed to observe the effects of 8 wk of treatment with formoterol (Foradil) 24 microgram, budesonide 400 microgram, and matched placebo inhaled twice a day on inflammatory indices in the bronchial mucosa of 64 patients with mild atopic asthma. Biopsies were obtained at the start and 1 wk before stopping a 9-wk period of treatment, and inflammatory cell numbers were assessed in the submucosa and epithelium by immunohistochemistry. Regular formoterol significantly reduced the number of submucosal mast cells, with a similar trend for eosinophils but not activated T cells. A subgroup analysis conducted in biopsies with >= 10 eosinophils per mm2 revealed a significant reduction in eosinophil numbers when compared with both pretreatment baseline (p < 0.01) and changes after placebo (p < 0.01). Parallel, but less pronounced, effects were observed on mast cell but not on CD25(+) T cell numbers. There was no effect of any of the three treatments on BAL levels of mast cell or eosinophil mediators. We conclude that regular treatment with inhaled formoterol reduces rather than increases inflammatory cells in the mucosa of asthmatic patients. It is possible that these cellular effects of formoterol may contribute to the therapeutic efficacy of this drug when used regularly in the treatment

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Published date: 1 January 1999

Identifiers

Local EPrints ID: 191015
URI: http://eprints.soton.ac.uk/id/eprint/191015
ISSN: 1073-449X
PURE UUID: 3981d165-bb01-4d61-8ff2-49421add4aea
ORCID for Susan J. Wilson: ORCID iD orcid.org/0000-0003-1305-8271
ORCID for Ratko Djukanović: ORCID iD orcid.org/0000-0001-6039-5612

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Date deposited: 21 Jun 2011 08:37
Last modified: 15 Mar 2024 02:36

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Contributors

Author: Annika Wallin
Author: Thomas Sandström
Author: Margaetha Söderberg
Author: Bo Lundbäck
Author: Giovanni Della-Cioppa
Author: Susan J. Wilson ORCID iD
Author: Mary Judd
Author: Anne Lindberg
Author: Lars Larssen
Author: Bo Melander

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