Temporal Optimization of Microfluidic Colorimetric Sensors by Use of Multiplexed Stop-Flow Architecture
Temporal Optimization of Microfluidic Colorimetric Sensors by Use of Multiplexed Stop-Flow Architecture
We present two microfluidic architectures (continuous flow and multiplexed stop flow) for miniaturized colorimetric nutrient sensors. These systems are compared with respect to the temporal response (for optimization of sampling rate) and reduction of reagent consumption. The continuous-flow system is capable of a sampling rate of 60 samples·h–1, limited by Taylor dispersion. The novel multiplexed stop-flow (MSF) microsystem architecture is not limited by dispersion. A demonstration MSF system consisting of two stop-flow channels is presented. This requires 12.6 s to load each sample into a measurement channel and when scaled would be capable of a throughput of 285 h–1 (with full color development). The MSF architecture is manufactured in PMMA/Viton/PMMA [where PMMA = poly(methyl methacrylate)], utilizes on-chip valving, and is scalable, thereby permitting sampling at much faster rates (subsecond). Either system is capable of remote deployment and continuous measurement of nutrient concentrations. The MSF system is particularly suited for applications requiring high temporal or spatial resolution; such as from moving vehicles.
4814-4821
Ogilvie, I.R.G.
fc08051a-1e06-4bb5-9d99-c93cf5e2e51d
Sieben, V.J.
402ed37e-1b54-425e-9b45-9e3d55902753
Mowlem, M.C.
6f633ca2-298f-48ee-a025-ce52dd62124f
Morgan, H.
de00d59f-a5a2-48c4-a99a-1d5dd7854174
2011
Ogilvie, I.R.G.
fc08051a-1e06-4bb5-9d99-c93cf5e2e51d
Sieben, V.J.
402ed37e-1b54-425e-9b45-9e3d55902753
Mowlem, M.C.
6f633ca2-298f-48ee-a025-ce52dd62124f
Morgan, H.
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Ogilvie, I.R.G., Sieben, V.J., Mowlem, M.C. and Morgan, H.
(2011)
Temporal Optimization of Microfluidic Colorimetric Sensors by Use of Multiplexed Stop-Flow Architecture.
Analytical Chemistry, 83 (12), .
(doi:10.1021/ac200463y).
Abstract
We present two microfluidic architectures (continuous flow and multiplexed stop flow) for miniaturized colorimetric nutrient sensors. These systems are compared with respect to the temporal response (for optimization of sampling rate) and reduction of reagent consumption. The continuous-flow system is capable of a sampling rate of 60 samples·h–1, limited by Taylor dispersion. The novel multiplexed stop-flow (MSF) microsystem architecture is not limited by dispersion. A demonstration MSF system consisting of two stop-flow channels is presented. This requires 12.6 s to load each sample into a measurement channel and when scaled would be capable of a throughput of 285 h–1 (with full color development). The MSF architecture is manufactured in PMMA/Viton/PMMA [where PMMA = poly(methyl methacrylate)], utilizes on-chip valving, and is scalable, thereby permitting sampling at much faster rates (subsecond). Either system is capable of remote deployment and continuous measurement of nutrient concentrations. The MSF system is particularly suited for applications requiring high temporal or spatial resolution; such as from moving vehicles.
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Published date: 2011
Organisations:
Ocean Technology and Engineering
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Local EPrints ID: 192321
URI: http://eprints.soton.ac.uk/id/eprint/192321
ISSN: 0003-2700
PURE UUID: 8b771cbc-a2e7-4f27-84ea-42fd0e3d39bc
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Date deposited: 01 Jul 2011 13:32
Last modified: 15 Mar 2024 03:18
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Author:
I.R.G. Ogilvie
Author:
V.J. Sieben
Author:
M.C. Mowlem
Author:
H. Morgan
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