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Crystal structure of a bacterial chitinase at 2.3 A resolution

Crystal structure of a bacterial chitinase at 2.3 A resolution
Crystal structure of a bacterial chitinase at 2.3 A resolution
The reaction mechanism seems to be similar to that of lysozyme and most other glycosylhydrolases, i.e. general acid-base catalysis. The role of the amino-terminal domain could not be identified, but it has similarities to the fibronectin III domain. This domain may possibly facilitate the interaction of chitinase A with chitin.
0969-2126
1169-1180
Perrakis, A
7ad07b49-d70d-49c6-ad26-d36386edb489
Tews, I
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Dauter, Z
ce05d008-c67d-485f-b818-124f89de445a
Oppenheim, A B
1331fbc0-5112-4acc-bff8-607a67368d7e
Chet, I
50e25601-914c-4b5f-bb21-fbb14f62a5a6
Wilson, K S
1fb580a1-8d72-4c2a-937a-63057f90b486
Vorgias, C E
061c2f8d-b5c5-46b7-8c92-976da23cbef5
Perrakis, A
7ad07b49-d70d-49c6-ad26-d36386edb489
Tews, I
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Dauter, Z
ce05d008-c67d-485f-b818-124f89de445a
Oppenheim, A B
1331fbc0-5112-4acc-bff8-607a67368d7e
Chet, I
50e25601-914c-4b5f-bb21-fbb14f62a5a6
Wilson, K S
1fb580a1-8d72-4c2a-937a-63057f90b486
Vorgias, C E
061c2f8d-b5c5-46b7-8c92-976da23cbef5

Perrakis, A, Tews, I, Dauter, Z, Oppenheim, A B, Chet, I, Wilson, K S and Vorgias, C E (1994) Crystal structure of a bacterial chitinase at 2.3 A resolution. Structure, 2 (12), 1169-1180. (doi:10.1016/S0969-2126(94)00119-7). (PMID:7704527)

Record type: Article

Abstract

The reaction mechanism seems to be similar to that of lysozyme and most other glycosylhydrolases, i.e. general acid-base catalysis. The role of the amino-terminal domain could not be identified, but it has similarities to the fibronectin III domain. This domain may possibly facilitate the interaction of chitinase A with chitin.

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Published date: 15 December 1994
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Organisations: Centre for Biological Sciences
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Identifiers

Local EPrints ID: 200661
URI: http://eprints.soton.ac.uk/id/eprint/200661
DOI: doi:10.1016/S0969-2126(94)00119-7
ISSN: 0969-2126
PURE UUID: 015b5b99-f308-490b-96cb-192fbf698257
ORCID for I Tews: ORCID iD orcid.org/0000-0002-4704-1139

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Date deposited: 02 Nov 2011 14:39
Last modified: 15 Mar 2024 03:36

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Contributors

Author: A Perrakis
Author: I Tews ORCID iD
Author: Z Dauter
Author: A B Oppenheim
Author: I Chet
Author: K S Wilson
Author: C E Vorgias

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