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Bromelain as a treatment for osteoarthritis: a review of clinical studies

Bromelain as a treatment for osteoarthritis: a review of clinical studies
Bromelain as a treatment for osteoarthritis: a review of clinical studies
Bromelain, an extract from the pineapple plant, has been demonstrated to show anti-inflammatory and analgesic properties and may provide a safer alternative or adjunctive treatment for osteoarthritis. All previous trials, which have been uncontrolled or comparative studies, indicate its potential use for the treatment of osteoarthritis. This paper reviews the mechanism of its putative therapeutic actions, those clinical trials that have assessed its use in osteoarthritis to date, as well as considering the safety implications of this supplement for osteoarthritis and reviewing the evidence to date regarding the dosage for treating this condition. The data available at present indicate the need for trials to establish the efficacy and optimum dosage for bromelain and the need for adequate prospective adverse event monitoring in such chronic conditions as osteoarthritis.
bromelain, herbal, osteoarthritis, proteolytic enzymes, review
1741-427X
251-257
Brien, Sarah
4e8e97cd-7bc3-4efd-857e-20790040b80f
Lewith, George
0fc483fa-f17b-47c5-94d9-5c15e65a7625
Walker, Ann
0d1f8be3-aeb1-4614-a48e-ffadef441aff
Hicks, Stephen M.
cd637d67-1742-4feb-a6f2-33a52e5bb742
Middleton, Dick
3c554b74-33a3-4628-a0f0-721ba8f53574
Brien, Sarah
4e8e97cd-7bc3-4efd-857e-20790040b80f
Lewith, George
0fc483fa-f17b-47c5-94d9-5c15e65a7625
Walker, Ann
0d1f8be3-aeb1-4614-a48e-ffadef441aff
Hicks, Stephen M.
cd637d67-1742-4feb-a6f2-33a52e5bb742
Middleton, Dick
3c554b74-33a3-4628-a0f0-721ba8f53574

Brien, Sarah, Lewith, George, Walker, Ann, Hicks, Stephen M. and Middleton, Dick (2004) Bromelain as a treatment for osteoarthritis: a review of clinical studies. Evidence-Based Complementary and Alternative Medicine, 1 (3), 251-257. (doi:10.1093/ecam/neh035).

Record type: Article

Abstract

Bromelain, an extract from the pineapple plant, has been demonstrated to show anti-inflammatory and analgesic properties and may provide a safer alternative or adjunctive treatment for osteoarthritis. All previous trials, which have been uncontrolled or comparative studies, indicate its potential use for the treatment of osteoarthritis. This paper reviews the mechanism of its putative therapeutic actions, those clinical trials that have assessed its use in osteoarthritis to date, as well as considering the safety implications of this supplement for osteoarthritis and reviewing the evidence to date regarding the dosage for treating this condition. The data available at present indicate the need for trials to establish the efficacy and optimum dosage for bromelain and the need for adequate prospective adverse event monitoring in such chronic conditions as osteoarthritis.

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More information

Published date: 2004
Keywords: bromelain, herbal, osteoarthritis, proteolytic enzymes, review

Identifiers

Local EPrints ID: 24282
URI: http://eprints.soton.ac.uk/id/eprint/24282
ISSN: 1741-427X
PURE UUID: bab151f1-ebcb-4c81-9219-bf5958310412
ORCID for Sarah Brien: ORCID iD orcid.org/0000-0003-1120-2364

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Date deposited: 31 Mar 2006
Last modified: 16 Mar 2024 03:19

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Contributors

Author: Sarah Brien ORCID iD
Author: George Lewith
Author: Ann Walker
Author: Stephen M. Hicks
Author: Dick Middleton

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