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Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants

Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants
Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants
Objective: The study was undertaken to determine the outcome of singleton pregnancies conceived through ovulation induction and intrauterine insemination using a partner's (OI/IUI) or donor sperm (OI/IUID) by comparison with naturally conceived singletons within a national cohort.
Study Design: Retrospective cohort study in primigravid women who were treated with OI/IUI (n = 97) or OI/IUID (n = 35) at Glasgow Royal Infirmary between March 1993 and March 1997 and identified within the Scottish national cohort (n = 109,443) delivering during the same period. Univariate and multivariate logistic regression models were used to examine outcomes and to determine the factors associated with infertility treatment and low birth weight.
Results: OI/IUI singletons were more likely to be lighter, of clinically low birth weight, and born more prematurely than natural conceptions. After adjustment for associated factors, these infants were 4.85 times (95% CI 2.25-10.48) more likely to be of low birth weight. We could not demonstrate any differences between OI/IUID and natural conceptions.
Conclusion: The perinatal outcome of singletons born to subfertile mothers conceived through OI/IUI is poorer than that of matched natural conceptions. We suggest that intrinsic factors in subfertile couples predispose them to having smaller infants and that "infertility" should be added to the list of recognized factors associated with low birth weight.
0002-9378
611-616
Gaudoin, Marco
2c6e0b20-10ee-4c61-89da-1aa1dfd44bb1
Dobbie, Richard
8d124995-2081-427c-9071-5d7d355feab3
Finlayson, Alan
9dda453b-3685-40df-a5c5-ab525714f31a
Chalmers, James
c46de188-749f-4977-ab5e-ca71d7087812
Cameron, Iain T.
f7595539-efa6-4687-b161-e1e93ff710f2
Fleming, Richard
278a1a21-0aaf-4001-a987-465eff7dc246
Gaudoin, Marco
2c6e0b20-10ee-4c61-89da-1aa1dfd44bb1
Dobbie, Richard
8d124995-2081-427c-9071-5d7d355feab3
Finlayson, Alan
9dda453b-3685-40df-a5c5-ab525714f31a
Chalmers, James
c46de188-749f-4977-ab5e-ca71d7087812
Cameron, Iain T.
f7595539-efa6-4687-b161-e1e93ff710f2
Fleming, Richard
278a1a21-0aaf-4001-a987-465eff7dc246

Gaudoin, Marco, Dobbie, Richard, Finlayson, Alan, Chalmers, James, Cameron, Iain T. and Fleming, Richard (2003) Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants. American Journal of Obstetrics and Gynecology, 188 (3), 611-616. (doi:10.1067/mob.2003.5).

Record type: Article

Abstract

Objective: The study was undertaken to determine the outcome of singleton pregnancies conceived through ovulation induction and intrauterine insemination using a partner's (OI/IUI) or donor sperm (OI/IUID) by comparison with naturally conceived singletons within a national cohort.
Study Design: Retrospective cohort study in primigravid women who were treated with OI/IUI (n = 97) or OI/IUID (n = 35) at Glasgow Royal Infirmary between March 1993 and March 1997 and identified within the Scottish national cohort (n = 109,443) delivering during the same period. Univariate and multivariate logistic regression models were used to examine outcomes and to determine the factors associated with infertility treatment and low birth weight.
Results: OI/IUI singletons were more likely to be lighter, of clinically low birth weight, and born more prematurely than natural conceptions. After adjustment for associated factors, these infants were 4.85 times (95% CI 2.25-10.48) more likely to be of low birth weight. We could not demonstrate any differences between OI/IUID and natural conceptions.
Conclusion: The perinatal outcome of singletons born to subfertile mothers conceived through OI/IUI is poorer than that of matched natural conceptions. We suggest that intrinsic factors in subfertile couples predispose them to having smaller infants and that "infertility" should be added to the list of recognized factors associated with low birth weight.

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More information

Published date: March 2003

Identifiers

Local EPrints ID: 25527
URI: http://eprints.soton.ac.uk/id/eprint/25527
ISSN: 0002-9378
PURE UUID: fa2ed960-db99-4e97-a31a-9d1c74ce3945
ORCID for Iain T. Cameron: ORCID iD orcid.org/0000-0002-4875-267X

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Date deposited: 11 Apr 2006
Last modified: 16 Mar 2024 03:00

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Contributors

Author: Marco Gaudoin
Author: Richard Dobbie
Author: Alan Finlayson
Author: James Chalmers
Author: Iain T. Cameron ORCID iD
Author: Richard Fleming

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