The University of Southampton
University of Southampton Institutional Repository

Effects of maternal iron restriction on placental vascularization in the rat

Effects of maternal iron restriction on placental vascularization in the rat
Effects of maternal iron restriction on placental vascularization in the rat
To investigate the effects of maternal iron deficiency and anaemia on the placenta the composition and vascularization of the placental labyrinth was investigated in iron-restricted rats. Rats in the experimental groups were placed on iron-restricted diets either 1 or 2 weeks before mating and continued on these diets throughout gestation. Placentae were studied at day 21 of gestation. Tissue sections were stained with lectin to allow identification of fetal capillaries and analyzed using stereological techniques. Capillary surface area density and total capillary surface area were decreased in both iron-restricted groups compared with the control group. Capillary length density was decreased in both iron-restricted groups compared with the control group. Total capillary length was significantly reduced in the 1-week, but not in the 2-week, iron-restricted group compared with the control group. Endothelial cell volume was increased in both iron-restricted groups compared to the controls. There were no significant differences in the volume of fetal capillaries, the volume of the maternal blood spaces or the surface area of the maternal–fetal interface between the control and iron-restricted groups. Labyrinthine volume, labyrinthine tissue volume and the surface area of the maternal fetal interface were increased in the 2-week group when compared with the 1-week group. These changes in placental vascularization may contribute to the fetal growth retardation observed in iron-restricted litters.
0143-4004
534-539
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Doherty, C.B.
6516823a-b092-4dc7-b142-f6af95532de7
James, L.A.
5a41e54b-d29f-40c8-bc57-c6e6716d64e4
Burton, G.J.
1383d522-1b90-41d2-9151-f81b8328bc66
Hales, C.N.
d3056fe8-da77-494b-ab8e-57207e92e0ea
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Doherty, C.B.
6516823a-b092-4dc7-b142-f6af95532de7
James, L.A.
5a41e54b-d29f-40c8-bc57-c6e6716d64e4
Burton, G.J.
1383d522-1b90-41d2-9151-f81b8328bc66
Hales, C.N.
d3056fe8-da77-494b-ab8e-57207e92e0ea

Lewis, R.M., Doherty, C.B., James, L.A., Burton, G.J. and Hales, C.N. (2001) Effects of maternal iron restriction on placental vascularization in the rat. Placenta, 22 (6), 534-539. (doi:10.1053/plac.2001.0679).

Record type: Article

Abstract

To investigate the effects of maternal iron deficiency and anaemia on the placenta the composition and vascularization of the placental labyrinth was investigated in iron-restricted rats. Rats in the experimental groups were placed on iron-restricted diets either 1 or 2 weeks before mating and continued on these diets throughout gestation. Placentae were studied at day 21 of gestation. Tissue sections were stained with lectin to allow identification of fetal capillaries and analyzed using stereological techniques. Capillary surface area density and total capillary surface area were decreased in both iron-restricted groups compared with the control group. Capillary length density was decreased in both iron-restricted groups compared with the control group. Total capillary length was significantly reduced in the 1-week, but not in the 2-week, iron-restricted group compared with the control group. Endothelial cell volume was increased in both iron-restricted groups compared to the controls. There were no significant differences in the volume of fetal capillaries, the volume of the maternal blood spaces or the surface area of the maternal–fetal interface between the control and iron-restricted groups. Labyrinthine volume, labyrinthine tissue volume and the surface area of the maternal fetal interface were increased in the 2-week group when compared with the 1-week group. These changes in placental vascularization may contribute to the fetal growth retardation observed in iron-restricted litters.

This record has no associated files available for download.

More information

Published date: 2001

Identifiers

Local EPrints ID: 25756
URI: http://eprints.soton.ac.uk/id/eprint/25756
ISSN: 0143-4004
PURE UUID: d2dd805f-e918-4435-b34b-9a1bfd7e2275
ORCID for R.M. Lewis: ORCID iD orcid.org/0000-0003-4044-9104

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 16 Mar 2024 03:21

Export record

Altmetrics

Contributors

Author: R.M. Lewis ORCID iD
Author: C.B. Doherty
Author: L.A. James
Author: G.J. Burton
Author: C.N. Hales

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×