The University of Southampton
University of Southampton Institutional Repository

Long-term programming of blood pressure by maternal dietary iron restriction in the rat

Long-term programming of blood pressure by maternal dietary iron restriction in the rat
Long-term programming of blood pressure by maternal dietary iron restriction in the rat
We have reported that blood pressure was elevated in 3-month-old rats whose mothers were Fe-restricted during pregnancy. These animals also had improved glucose tolerance and decreased serum triacylglycerol. The aim of the present study was to determine whether these effects of maternal nutritional restriction, present in these animals at 3 months of age, can be observed in the same animals in later life. Pulmonary and serum angiotensin converting enzyme (ACE) concentrations were also measured to investigate whether the renin-angiotensin system was involved in the elevation of blood pressure observed in the offspring of Fe-restricted dams. Systolic blood pressure was higher in the offspring of Fe-restricted dams at 16 months of age. Heart and kidney weight were increased as a proportion of body weight in the offspring of Fe-restricted dams. The pulmonary ACE concentration was not significantly different between the groups. The serum ACE concentration was significantly elevated in the offspring of Fe-restricted dams at 3 but not 14 months of age. There was a strong correlation between serum ACE levels at 3 and 14 months of age. Glucose tolerance and serum insulin were not different between the maternal diet groups. Serum triacylglycerol tended to be lower in the offspring of Fe-restricted dams. There were no differences in serum non-esterified fatty acids or serum cholesterol between the maternal diet groups. This study provides further evidence that maternal nutrition has effects on the offspring that persist throughout life. At 16 months of age, the elevation of blood pressure in Fe-restricted offspring does not appear to be mediated via changes in ACE levels. Both cardiac hypertrophy and decreased serum triacylglycerol have also been observed in Fe-restricted fetuses, suggesting that these changes may be initiated in utero.
maternal iron deficiency, growth retardation, blood pressure, triacylglycerol
0007-1145
283-290
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Forhead, A.J.
dec89871-0e54-4819-8261-8cd42f6b3f02
Petry, C.J.
02618611-3a43-4f9c-91ab-60d4b9d3d79c
Ozanne, S.E.
765ced2c-1256-4943-89b6-083d6b585cca
Hales, C.N.
d3056fe8-da77-494b-ab8e-57207e92e0ea
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Forhead, A.J.
dec89871-0e54-4819-8261-8cd42f6b3f02
Petry, C.J.
02618611-3a43-4f9c-91ab-60d4b9d3d79c
Ozanne, S.E.
765ced2c-1256-4943-89b6-083d6b585cca
Hales, C.N.
d3056fe8-da77-494b-ab8e-57207e92e0ea

Lewis, R.M., Forhead, A.J., Petry, C.J., Ozanne, S.E. and Hales, C.N. (2002) Long-term programming of blood pressure by maternal dietary iron restriction in the rat. British Journal of Nutrition, 88 (3), 283-290. (doi:10.1079/BJN2002656).

Record type: Article

Abstract

We have reported that blood pressure was elevated in 3-month-old rats whose mothers were Fe-restricted during pregnancy. These animals also had improved glucose tolerance and decreased serum triacylglycerol. The aim of the present study was to determine whether these effects of maternal nutritional restriction, present in these animals at 3 months of age, can be observed in the same animals in later life. Pulmonary and serum angiotensin converting enzyme (ACE) concentrations were also measured to investigate whether the renin-angiotensin system was involved in the elevation of blood pressure observed in the offspring of Fe-restricted dams. Systolic blood pressure was higher in the offspring of Fe-restricted dams at 16 months of age. Heart and kidney weight were increased as a proportion of body weight in the offspring of Fe-restricted dams. The pulmonary ACE concentration was not significantly different between the groups. The serum ACE concentration was significantly elevated in the offspring of Fe-restricted dams at 3 but not 14 months of age. There was a strong correlation between serum ACE levels at 3 and 14 months of age. Glucose tolerance and serum insulin were not different between the maternal diet groups. Serum triacylglycerol tended to be lower in the offspring of Fe-restricted dams. There were no differences in serum non-esterified fatty acids or serum cholesterol between the maternal diet groups. This study provides further evidence that maternal nutrition has effects on the offspring that persist throughout life. At 16 months of age, the elevation of blood pressure in Fe-restricted offspring does not appear to be mediated via changes in ACE levels. Both cardiac hypertrophy and decreased serum triacylglycerol have also been observed in Fe-restricted fetuses, suggesting that these changes may be initiated in utero.

This record has no associated files available for download.

More information

Published date: 2002
Keywords: maternal iron deficiency, growth retardation, blood pressure, triacylglycerol

Identifiers

Local EPrints ID: 25758
URI: http://eprints.soton.ac.uk/id/eprint/25758
ISSN: 0007-1145
PURE UUID: 6ff8cfe1-3a93-47bf-9903-dc6590526109
ORCID for R.M. Lewis: ORCID iD orcid.org/0000-0003-4044-9104

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 16 Mar 2024 03:21

Export record

Altmetrics

Contributors

Author: R.M. Lewis ORCID iD
Author: A.J. Forhead
Author: C.J. Petry
Author: S.E. Ozanne
Author: C.N. Hales

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×