Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged Caucasian men
Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged Caucasian men
The insulin-sensitizing effect of adiponectin (1–4) is mediated via adiponectin receptors (AdipoR1 and AdipoR2) (5). AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is also expressed in the liver, with lower levels of expression in skeletal muscle (5). Both receptors are expressed in adipose tissue (6) and pancreatic ß-cells (7).
It has been shown recently that expression of AdipoRs in human skeletal muscle is correlated with insulin sensitivity (8). Because central obesity is associated with insulin resistance, we have undertaken detailed measurements of body fatness with bioimpedance, dual-energy X-ray absorbtiometry (DEXA), and five-slice magnetic resonance imaging (MRI) through the abdomen. We have determined whether expression of AdipoRs was associated with body fatness and in particular with measures of central obesity.
2058-2060
Zhang, Junlong
68a8fa77-c5db-4b34-aa9a-fbad6860155f
Holt, Helen
91299fb2-77f1-422f-81fa-86d5fdd0b1fb
Wang, Chunli
d9ec88ea-e4c5-41de-9ffc-4059aac94098
Hadid, Omar H.
3bc92793-4cc5-4595-925b-0bf4760d88ff
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
August 2005
Zhang, Junlong
68a8fa77-c5db-4b34-aa9a-fbad6860155f
Holt, Helen
91299fb2-77f1-422f-81fa-86d5fdd0b1fb
Wang, Chunli
d9ec88ea-e4c5-41de-9ffc-4059aac94098
Hadid, Omar H.
3bc92793-4cc5-4595-925b-0bf4760d88ff
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Zhang, Junlong, Holt, Helen, Wang, Chunli, Hadid, Omar H. and Byrne, Christopher D.
(2005)
Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged Caucasian men.
Diabetes Care, 28 (8), .
(doi:10.2337/diacare.28.8.2058).
Abstract
The insulin-sensitizing effect of adiponectin (1–4) is mediated via adiponectin receptors (AdipoR1 and AdipoR2) (5). AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is also expressed in the liver, with lower levels of expression in skeletal muscle (5). Both receptors are expressed in adipose tissue (6) and pancreatic ß-cells (7).
It has been shown recently that expression of AdipoRs in human skeletal muscle is correlated with insulin sensitivity (8). Because central obesity is associated with insulin resistance, we have undertaken detailed measurements of body fatness with bioimpedance, dual-energy X-ray absorbtiometry (DEXA), and five-slice magnetic resonance imaging (MRI) through the abdomen. We have determined whether expression of AdipoRs was associated with body fatness and in particular with measures of central obesity.
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Published date: August 2005
Additional Information:
Pathophysiology/complications: brief report
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Local EPrints ID: 26156
URI: http://eprints.soton.ac.uk/id/eprint/26156
ISSN: 1935-5548
PURE UUID: 1bc97dde-591d-42b9-b6d4-0fe30504a5b6
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Date deposited: 19 Apr 2006
Last modified: 16 Mar 2024 03:07
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Author:
Junlong Zhang
Author:
Helen Holt
Author:
Chunli Wang
Author:
Omar H. Hadid
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