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The processing of antigens delivered as DNA vaccines

The processing of antigens delivered as DNA vaccines
The processing of antigens delivered as DNA vaccines
The ability of DNA vaccines to provide effective immunological protection against infection and tumors depends on their ability to generate good CD4+ and CD8+ T-cell responses. Priming of these responses is a property of dendritic cells (DCs), and so the efficacy of DNA-encoded vaccines is likely to depend on the way in which the antigens they encode are processed by DCs. This processing could either be via the synthesis of the vaccine-encoded antigen by the DCs themselves or via its uptake by DCs following its synthesis in bystander cells that are unable to prime T cells. These different sources of antigen are likely to engage different antigen-processing pathways, which are the subject of this review. Understanding how to access different processing pathways in DCs may ultimately aid the rational development of plasmid-based vaccines to pathogens and to cancer.
0105-2896
27-39
Howarth, M.
3029a285-092c-4fae-8b03-d8c5d2dd73cc
Elliott, T.
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Howarth, M.
3029a285-092c-4fae-8b03-d8c5d2dd73cc
Elliott, T.
16670fa8-c2f9-477a-91df-7c9e5b453e0e

Howarth, M. and Elliott, T. (2004) The processing of antigens delivered as DNA vaccines. Immunological Reviews, 199 (1), 27-39. (doi:10.1111/j.0105-2896.2004.00141.x).

Record type: Article

Abstract

The ability of DNA vaccines to provide effective immunological protection against infection and tumors depends on their ability to generate good CD4+ and CD8+ T-cell responses. Priming of these responses is a property of dendritic cells (DCs), and so the efficacy of DNA-encoded vaccines is likely to depend on the way in which the antigens they encode are processed by DCs. This processing could either be via the synthesis of the vaccine-encoded antigen by the DCs themselves or via its uptake by DCs following its synthesis in bystander cells that are unable to prime T cells. These different sources of antigen are likely to engage different antigen-processing pathways, which are the subject of this review. Understanding how to access different processing pathways in DCs may ultimately aid the rational development of plasmid-based vaccines to pathogens and to cancer.

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Published date: June 2004

Identifiers

Local EPrints ID: 26389
URI: http://eprints.soton.ac.uk/id/eprint/26389
ISSN: 0105-2896
PURE UUID: 9bc8010d-ae00-431b-bb7c-9d9763ea193e
ORCID for T. Elliott: ORCID iD orcid.org/0000-0003-1097-0222

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Date deposited: 19 Apr 2006
Last modified: 16 Mar 2024 03:19

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Contributors

Author: M. Howarth
Author: T. Elliott ORCID iD

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