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Systemic cytokine levels in community-acquired pneumonia and their association with disease severity

Systemic cytokine levels in community-acquired pneumonia and their association with disease severity
Systemic cytokine levels in community-acquired pneumonia and their association with disease severity
Pro-inflammatory and anti-inflammatory cytokines are important mediators in the host response to infection. In contrast to the pro-inflammatory cytokines little is known about anti-inflammatory cytokines in community-acquired pneumonia (CAP) and their relation to disease severity.
Circulating levels of three pro-inflammatory cytokines (interleukin (IL)-1ß, IL-6 and tumour necrosis factor (TNF)-) and two anti-inflammatory cytokines (IL-10, IL-1 receptor antagonist (IL-1ra)) were measured using an enzyme immunoassay on admission, day 3 and day 5 in 24 patients with CAP. The modified British Thoracic Society (BTS) prognostic rule and Acute Physiology and Chronic Health Evaluation (APACHE) II score were used to assess disease severity.
IL-6, TNF-, IL-10 and IL-1ra concentrations were detected in most patients on admission and decreased significantly on day 3 and day 5 in all survivors. A significant difference between the BTS high-risk and low-risk groups was only found for IL-6 (median (range) 477 pg·mL–1 (7.6–1402 pg·mL–1) versus 81.6 pg·mL–1 (0–943 pg·mL–1); p<0.05). IL-6 also correlated with the APACHE II scores on admission.
Concentrations of anti-inflammatory cytokines were elevated on admission in community-acquired pneumonia but they did not correlate with disease severity scores.
community-acquired, pneumonia, cytokines, disease severity score
0903-1936
990-995
Antunes, G.
46a06109-26f1-4638-a121-9dd1a02f809d
Evans, S.A.
98b90bc9-59e9-4b49-9278-feb65493ead5
Lordan, J.L.
d63dce9d-b04e-4eb5-a251-ba0d12c443dc
Frew, A.J.
c00e9630-a5f0-44b3-add0-44b68836bbcb
Antunes, G.
46a06109-26f1-4638-a121-9dd1a02f809d
Evans, S.A.
98b90bc9-59e9-4b49-9278-feb65493ead5
Lordan, J.L.
d63dce9d-b04e-4eb5-a251-ba0d12c443dc
Frew, A.J.
c00e9630-a5f0-44b3-add0-44b68836bbcb

Antunes, G., Evans, S.A., Lordan, J.L. and Frew, A.J. (2002) Systemic cytokine levels in community-acquired pneumonia and their association with disease severity. European Respiratory Journal, 20 (4), 990-995. (doi:10.1183/09031936.02.00295102).

Record type: Article

Abstract

Pro-inflammatory and anti-inflammatory cytokines are important mediators in the host response to infection. In contrast to the pro-inflammatory cytokines little is known about anti-inflammatory cytokines in community-acquired pneumonia (CAP) and their relation to disease severity.
Circulating levels of three pro-inflammatory cytokines (interleukin (IL)-1ß, IL-6 and tumour necrosis factor (TNF)-) and two anti-inflammatory cytokines (IL-10, IL-1 receptor antagonist (IL-1ra)) were measured using an enzyme immunoassay on admission, day 3 and day 5 in 24 patients with CAP. The modified British Thoracic Society (BTS) prognostic rule and Acute Physiology and Chronic Health Evaluation (APACHE) II score were used to assess disease severity.
IL-6, TNF-, IL-10 and IL-1ra concentrations were detected in most patients on admission and decreased significantly on day 3 and day 5 in all survivors. A significant difference between the BTS high-risk and low-risk groups was only found for IL-6 (median (range) 477 pg·mL–1 (7.6–1402 pg·mL–1) versus 81.6 pg·mL–1 (0–943 pg·mL–1); p<0.05). IL-6 also correlated with the APACHE II scores on admission.
Concentrations of anti-inflammatory cytokines were elevated on admission in community-acquired pneumonia but they did not correlate with disease severity scores.

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More information

Published date: 2002
Keywords: community-acquired, pneumonia, cytokines, disease severity score

Identifiers

Local EPrints ID: 26908
URI: http://eprints.soton.ac.uk/id/eprint/26908
ISSN: 0903-1936
PURE UUID: e308362c-21fb-440e-9998-74c47137cc27

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Date deposited: 25 Apr 2006
Last modified: 15 Mar 2024 07:14

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Contributors

Author: G. Antunes
Author: S.A. Evans
Author: J.L. Lordan
Author: A.J. Frew

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