[Genetic factors involved in asthma and atopy. Studies in British families]
[Genetic factors involved in asthma and atopy. Studies in British families]
Both asthma and atopy run families indicating a strong genetic component. To investigate possible candidate gene regions, we have recruited 131 families without reference to atopy and asthma (random sample) and 60 extended families with two or more members affected by asthma (multiplex sample). Using both candidate and genome screen approaches, we have been able to provide evidence supporting the presence of candidate genes on chromosome 11q (E237G) and 12q but we have been unable to confirm reports of linkage and association for asthma on 5q. Our experience to date suggests that larger numbers of families are needed to increase the confidence of gene localisation and there is a need to improve the phenotypic description of asthma. Finally, it is essential that claims for linkage or association are confirmed in different populations using the same markers.
177-182
Thomas, N.S.
df2d7c6d-2c96-4aaa-a7ef-7f7987759cf4
Wilkinson, J.
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Lio, P.
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Doull, I.
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Morton, N.E.
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Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
2000
Thomas, N.S.
df2d7c6d-2c96-4aaa-a7ef-7f7987759cf4
Wilkinson, J.
fb7e8304-8448-49f0-9b4d-e52cdb9027fd
Lio, P.
670129ba-a283-4c05-875d-bbf8b21c471a
Doull, I.
2ec63854-1b37-4577-8c41-54e32b25a4a3
Morton, N.E.
c668e2be-074a-4a0a-a2ca-e8f51830ebb7
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Thomas, N.S., Wilkinson, J., Lio, P., Doull, I., Morton, N.E. and Holgate, S.T.
(2000)
[Genetic factors involved in asthma and atopy. Studies in British families].
Revue des Maladies Respiratoires, 17 (1 Pt 2), .
Abstract
Both asthma and atopy run families indicating a strong genetic component. To investigate possible candidate gene regions, we have recruited 131 families without reference to atopy and asthma (random sample) and 60 extended families with two or more members affected by asthma (multiplex sample). Using both candidate and genome screen approaches, we have been able to provide evidence supporting the presence of candidate genes on chromosome 11q (E237G) and 12q but we have been unable to confirm reports of linkage and association for asthma on 5q. Our experience to date suggests that larger numbers of families are needed to increase the confidence of gene localisation and there is a need to improve the phenotypic description of asthma. Finally, it is essential that claims for linkage or association are confirmed in different populations using the same markers.
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Published date: 2000
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Local EPrints ID: 27449
URI: http://eprints.soton.ac.uk/id/eprint/27449
PURE UUID: f2a1b1bb-7006-44e3-b902-6db905561985
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Date deposited: 15 Jun 2006
Last modified: 08 Jan 2022 06:54
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Author:
N.S. Thomas
Author:
J. Wilkinson
Author:
P. Lio
Author:
I. Doull
Author:
N.E. Morton
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