A comparison of twice-weekly MPD-PUVA and three times-weekly skin typing-PUVA regimens for the treatment of psoriasis
A comparison of twice-weekly MPD-PUVA and three times-weekly skin typing-PUVA regimens for the treatment of psoriasis
The most frequent PUVA treatment regimen in current use is three times weekly, using skin typing to estimate the starting dose. Recently, it was suggested that twice-weekly treatment, using the minimal phototoxic dose (MPD) to calculate suberythemal starting doses of UVA, achieved similar clearance rates with fewer treatments and a lower cumulative UVA dose. We have carried out a trial on 83 patients, comparing twice-weekly MPD-PUVA with three times-weekly skin typing-PUVA, in order to test this hypothesis. Although clearance rates were comparable between the two regimens, there was no overall significant difference in the number of treatments or in the cumulative UVA doses at clearance. However, for patients with skin types I and II the cumulative UVA dose was significantly higher using the twice-weekly MPD regimen (70.0 J/cm2 vs. 55.8 J/cm2; P<0.05). Our results do not confirm that there is a reduction in cumulative UVA dosage with twice-weekly MPD-PUVA.
417-422
Buckley, D.A.
cdba6eba-dbdc-400d-814a-b7f14e33d4ba
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Rogers, S.
710da411-1d64-4196-9742-2aac275abe3a
September 1995
Buckley, D.A.
cdba6eba-dbdc-400d-814a-b7f14e33d4ba
Healy, E.
400fc04d-f81a-474a-ae25-7ff894be0ebd
Rogers, S.
710da411-1d64-4196-9742-2aac275abe3a
Buckley, D.A., Healy, E. and Rogers, S.
(1995)
A comparison of twice-weekly MPD-PUVA and three times-weekly skin typing-PUVA regimens for the treatment of psoriasis.
British Journal of Dermatology, 133 (3), .
(doi:10.1111/j.1365-2133.1995.tb02670.x).
(PMID:8546997)
Abstract
The most frequent PUVA treatment regimen in current use is three times weekly, using skin typing to estimate the starting dose. Recently, it was suggested that twice-weekly treatment, using the minimal phototoxic dose (MPD) to calculate suberythemal starting doses of UVA, achieved similar clearance rates with fewer treatments and a lower cumulative UVA dose. We have carried out a trial on 83 patients, comparing twice-weekly MPD-PUVA with three times-weekly skin typing-PUVA, in order to test this hypothesis. Although clearance rates were comparable between the two regimens, there was no overall significant difference in the number of treatments or in the cumulative UVA doses at clearance. However, for patients with skin types I and II the cumulative UVA dose was significantly higher using the twice-weekly MPD regimen (70.0 J/cm2 vs. 55.8 J/cm2; P<0.05). Our results do not confirm that there is a reduction in cumulative UVA dosage with twice-weekly MPD-PUVA.
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Published date: September 1995
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 334168
URI: http://eprints.soton.ac.uk/id/eprint/334168
ISSN: 0007-0963
PURE UUID: c1252022-089d-495d-a139-70affa73da2b
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Date deposited: 16 Mar 2012 10:25
Last modified: 14 Mar 2024 10:34
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Author:
D.A. Buckley
Author:
S. Rogers
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