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Natural killer cells and hepatitis C: action and reaction

Natural killer cells and hepatitis C: action and reaction
Natural killer cells and hepatitis C: action and reaction
In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for human non-A, non-B hepatitis. Two decades later, HCV remains a global public health problem with a suboptimal response rate to treatment and the absence of a protective vaccine. Recent work has highlighted the influence of the innate immune system, and in particular natural killer cells, on the outcome and pathology of HCV infection. These cells are considerably more complex than was originally thought and their role in viral infections is currently being unravelled. This review summarises our emerging understanding of natural killer cells in HCV infection.
natural killer cells, immunology, hepatitis C
0017-5749
268-278
Cheent, Kuldeep
fc998259-3582-4bb3-ae11-58e418666bbc
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Cheent, Kuldeep
fc998259-3582-4bb3-ae11-58e418666bbc
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273

Cheent, Kuldeep and Khakoo, Salim I. (2011) Natural killer cells and hepatitis C: action and reaction. Gut, 60 (2), 268-278. (doi:10.1136/gut.2010.212555). (PMID:20876777)

Record type: Article

Abstract

In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for human non-A, non-B hepatitis. Two decades later, HCV remains a global public health problem with a suboptimal response rate to treatment and the absence of a protective vaccine. Recent work has highlighted the influence of the innate immune system, and in particular natural killer cells, on the outcome and pathology of HCV infection. These cells are considerably more complex than was originally thought and their role in viral infections is currently being unravelled. This review summarises our emerging understanding of natural killer cells in HCV infection.

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More information

Published date: February 2011
Keywords: natural killer cells, immunology, hepatitis C
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 336177
URI: http://eprints.soton.ac.uk/id/eprint/336177
DOI: doi:10.1136/gut.2010.212555
ISSN: 0017-5749
PURE UUID: 4e38d9a4-894b-4eb9-b623-b9e5f8a0ca45
ORCID for Salim I. Khakoo: ORCID iD orcid.org/0000-0002-4057-9091

Catalogue record

Date deposited: 16 Mar 2012 12:55
Last modified: 15 Mar 2024 03:12

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Contributors

Author: Kuldeep Cheent
Author: Salim I. Khakoo ORCID iD

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