Clostridium difficile PCR ribotype 027: assessing the risks of further worldwide spread
Clostridium difficile PCR ribotype 027: assessing the risks of further worldwide spread
Highly virulent strains of Clostridium difficile have emerged since 2003, causing large outbreaks of severe, often fatal, colitis in North America and Europe. In 2008-10, virulent strains spread between continents, with the first reported cases of fluoroquinolone-resistant C difficile PCR ribotype 027 in three Asia-Pacific countries and Central America. We present a risk assessment framework for assessing risks of further worldwide spread of this pathogen. This framework first requires identification of potential vehicles of introduction, including international transfers of hospital patients, international tourism and migration, and trade in livestock, associated commodities, and foodstuffs. It then calls for assessment of the risks of pathogen release, of exposure of individuals if release happens, and of resulting outbreaks. Health departments in countries unaffected by outbreaks should assess the risk of introduction or reintroduction of C difficile PCR ribotype 027 using a structured risk-assessment approach.
asia, bacterial typing techniques, central america, clostridium difficile, classification, genetics, isolation and purification, disease outbreaks, drug resistance, bacterial enterocolitis, pseudomembranous, epidemiology, microbiology, europe, humans, north america, ribotyping risk assessment
395-404
Clements, A.C.
26bb7239-e58c-4f3e-a5ce-97817fb85962
Magalhaes, R.J.
92a52b97-0e25-4495-9497-c516522880fb
Tatem, A.J.
6c6de104-a5f9-46e0-bb93-a1a7c980513e
Paterson, D.L.
d09316f7-0dd8-4a8b-9d92-dcf94a07c983
Riley, T.V.
41e0286b-ce44-46c6-8e56-f229773ff659
June 2010
Clements, A.C.
26bb7239-e58c-4f3e-a5ce-97817fb85962
Magalhaes, R.J.
92a52b97-0e25-4495-9497-c516522880fb
Tatem, A.J.
6c6de104-a5f9-46e0-bb93-a1a7c980513e
Paterson, D.L.
d09316f7-0dd8-4a8b-9d92-dcf94a07c983
Riley, T.V.
41e0286b-ce44-46c6-8e56-f229773ff659
Clements, A.C., Magalhaes, R.J., Tatem, A.J., Paterson, D.L. and Riley, T.V.
(2010)
Clostridium difficile PCR ribotype 027: assessing the risks of further worldwide spread.
The Lancet Infectious Diseases, 10 (6), .
(doi:10.1016/S1473-3099(10)70080-3).
(PMID:20510280)
Abstract
Highly virulent strains of Clostridium difficile have emerged since 2003, causing large outbreaks of severe, often fatal, colitis in North America and Europe. In 2008-10, virulent strains spread between continents, with the first reported cases of fluoroquinolone-resistant C difficile PCR ribotype 027 in three Asia-Pacific countries and Central America. We present a risk assessment framework for assessing risks of further worldwide spread of this pathogen. This framework first requires identification of potential vehicles of introduction, including international transfers of hospital patients, international tourism and migration, and trade in livestock, associated commodities, and foodstuffs. It then calls for assessment of the risks of pathogen release, of exposure of individuals if release happens, and of resulting outbreaks. Health departments in countries unaffected by outbreaks should assess the risk of introduction or reintroduction of C difficile PCR ribotype 027 using a structured risk-assessment approach.
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Published date: June 2010
Keywords:
asia, bacterial typing techniques, central america, clostridium difficile, classification, genetics, isolation and purification, disease outbreaks, drug resistance, bacterial enterocolitis, pseudomembranous, epidemiology, microbiology, europe, humans, north america, ribotyping risk assessment
Organisations:
Geography & Environment, PHEW – P (Population Health)
Identifiers
Local EPrints ID: 344409
URI: http://eprints.soton.ac.uk/id/eprint/344409
ISSN: 1473-3099
PURE UUID: 0040b818-4bb4-49a4-a809-837b83d84b1b
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Date deposited: 05 Nov 2012 16:38
Last modified: 15 Mar 2024 03:43
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Contributors
Author:
A.C. Clements
Author:
R.J. Magalhaes
Author:
D.L. Paterson
Author:
T.V. Riley
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