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Characterizing the ADHD phenotype for genetic studies

Characterizing the ADHD phenotype for genetic studies
Characterizing the ADHD phenotype for genetic studies
The genetic study of ADHD has made considerable progress. Further developments in the field will be reliant in part on identifying the most appropriate phenotypes for genetic analysis. The use of both categorical and dimensional measures of symptoms related to ADHD has been productive. The use of multiple reporters is a valuable feature of the characterization of psychopathology in children. It is argued that the use of aggregated measures to characterize the ADHD phenotype, particularly to establish its pervasiveness, is desirable. The recognition of the multiple comorbidities of ADHD can help to isolate more specific genetic influences. In relation to both reading disability and conduct disorder there is evidence that genes may be involved in the comorbid condition that are different from pure ADHD. To date, progress with the investigation of endophenotypes for ADHD has been disappointing. It is suggested that extending such studies beyond cognitive underpinnings to include physiological and metabolic markers might facilitate progress.
115-121
Stevenson, Jim
0c85d29b-d294-43cb-ab8d-75e4737478e1
Asherson, Phil
00df4670-3f15-4103-8b24-44f6265fcc93
Hay, David
249e6acb-ec3b-4c31-8358-2b7a77b9c6d4
Levy, Florence
0a8a5bba-08b1-4898-8984-501ef0d39c18
Swanson, Jim
f2324eb3-9a20-4036-847b-f49b220ce45b
Thapar, Anita
224b4dc1-a6ee-455a-95f9-b9a716606aa6
Willcutt, Erik
5f7dd498-8db3-44fc-bd28-c0a43321ccee
Stevenson, Jim
0c85d29b-d294-43cb-ab8d-75e4737478e1
Asherson, Phil
00df4670-3f15-4103-8b24-44f6265fcc93
Hay, David
249e6acb-ec3b-4c31-8358-2b7a77b9c6d4
Levy, Florence
0a8a5bba-08b1-4898-8984-501ef0d39c18
Swanson, Jim
f2324eb3-9a20-4036-847b-f49b220ce45b
Thapar, Anita
224b4dc1-a6ee-455a-95f9-b9a716606aa6
Willcutt, Erik
5f7dd498-8db3-44fc-bd28-c0a43321ccee

Stevenson, Jim, Asherson, Phil, Hay, David, Levy, Florence, Swanson, Jim, Thapar, Anita and Willcutt, Erik (2005) Characterizing the ADHD phenotype for genetic studies. Developmental Science, 8 (2), 115-121. (doi:10.1111/j.1467-7687.2005.00398.x).

Record type: Article

Abstract

The genetic study of ADHD has made considerable progress. Further developments in the field will be reliant in part on identifying the most appropriate phenotypes for genetic analysis. The use of both categorical and dimensional measures of symptoms related to ADHD has been productive. The use of multiple reporters is a valuable feature of the characterization of psychopathology in children. It is argued that the use of aggregated measures to characterize the ADHD phenotype, particularly to establish its pervasiveness, is desirable. The recognition of the multiple comorbidities of ADHD can help to isolate more specific genetic influences. In relation to both reading disability and conduct disorder there is evidence that genes may be involved in the comorbid condition that are different from pure ADHD. To date, progress with the investigation of endophenotypes for ADHD has been disappointing. It is suggested that extending such studies beyond cognitive underpinnings to include physiological and metabolic markers might facilitate progress.

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Published date: 2005

Identifiers

Local EPrints ID: 40128
URI: http://eprints.soton.ac.uk/id/eprint/40128
PURE UUID: 943151f7-33f0-4c2e-a367-4cc47cc94fec

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Date deposited: 03 Jul 2006
Last modified: 15 Mar 2024 08:17

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Contributors

Author: Jim Stevenson
Author: Phil Asherson
Author: David Hay
Author: Florence Levy
Author: Jim Swanson
Author: Anita Thapar
Author: Erik Willcutt

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