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Intact negative patterning in rats with fornix or combined perirhinal and postrhinal cortex lesions

Intact negative patterning in rats with fornix or combined perirhinal and postrhinal cortex lesions
Intact negative patterning in rats with fornix or combined perirhinal and postrhinal cortex lesions
It has been proposed that the hippocampal formation is necessary for the acquisition of tasks that require the use of configural representations for their solution, including spatial learning and negative patterning. Tests of this influential view have, however, yielded conflicting results. For example fornix or hippocampal lesions, which reliably impair spatial learning, do not reliably impair negative patterning. A problem in interpreting these results has been the lack of controls for factors such as over-responding, excitatory effects of reward, and the possibility of non-configural solutions. At the same time, other studies have pointed to a role in configural learning for parahippocampal regions such as the perirhinal cortex. The present experiments controlled for the above factors and revealed that neither lesions of the fornix nor of the perirhinal/postrhinal cortex in the rat had any effect on negative patterning, although subsequent tests of object and spatial memory demonstrated the functional efficacy of the lesions.
hippocampus, negative patterning, object discrimination, autoshaping, inferotemporal cortex
0014-4819
506-519
Bussey, Timothy J.
472f7e69-6465-4d88-9301-8c6e26fcae72
Dias, Rebecca
9ef4e1ed-639c-4d75-9dd2-2261987badc8
Redhead, Edward S.
d2342759-2c77-45ef-ac0f-9f70aa5db0df
Pearce, John M.
0448ba7f-c537-41ce-8c45-14c869414c88
Muir, Janice L.
ddc7d057-3a4d-46c0-a16b-58ada140dc2f
Aggleton, John P.
8c4b5dcb-69e3-4f32-af11-f47d5eb99aec
Bussey, Timothy J.
472f7e69-6465-4d88-9301-8c6e26fcae72
Dias, Rebecca
9ef4e1ed-639c-4d75-9dd2-2261987badc8
Redhead, Edward S.
d2342759-2c77-45ef-ac0f-9f70aa5db0df
Pearce, John M.
0448ba7f-c537-41ce-8c45-14c869414c88
Muir, Janice L.
ddc7d057-3a4d-46c0-a16b-58ada140dc2f
Aggleton, John P.
8c4b5dcb-69e3-4f32-af11-f47d5eb99aec

Bussey, Timothy J., Dias, Rebecca, Redhead, Edward S., Pearce, John M., Muir, Janice L. and Aggleton, John P. (2000) Intact negative patterning in rats with fornix or combined perirhinal and postrhinal cortex lesions. Experimental Brain Research, 134 (4), 506-519. (doi:10.1007/s002210000481).

Record type: Article

Abstract

It has been proposed that the hippocampal formation is necessary for the acquisition of tasks that require the use of configural representations for their solution, including spatial learning and negative patterning. Tests of this influential view have, however, yielded conflicting results. For example fornix or hippocampal lesions, which reliably impair spatial learning, do not reliably impair negative patterning. A problem in interpreting these results has been the lack of controls for factors such as over-responding, excitatory effects of reward, and the possibility of non-configural solutions. At the same time, other studies have pointed to a role in configural learning for parahippocampal regions such as the perirhinal cortex. The present experiments controlled for the above factors and revealed that neither lesions of the fornix nor of the perirhinal/postrhinal cortex in the rat had any effect on negative patterning, although subsequent tests of object and spatial memory demonstrated the functional efficacy of the lesions.

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More information

Published date: 2000
Keywords: hippocampus, negative patterning, object discrimination, autoshaping, inferotemporal cortex

Identifiers

Local EPrints ID: 40232
URI: http://eprints.soton.ac.uk/id/eprint/40232
ISSN: 0014-4819
PURE UUID: 1ca9c6d7-1740-4c44-a2cc-b0da10e05163
ORCID for Edward S. Redhead: ORCID iD orcid.org/0000-0002-7771-1228

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Date deposited: 18 Jul 2006
Last modified: 16 Mar 2024 03:18

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Contributors

Author: Timothy J. Bussey
Author: Rebecca Dias
Author: John M. Pearce
Author: Janice L. Muir
Author: John P. Aggleton

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