Infection of Drosophila melanogaster by Tubulinosema kingi: stage-specific susceptibility and within-host proliferation
Infection of Drosophila melanogaster by Tubulinosema kingi: stage-specific susceptibility and within-host proliferation
Despite its importance as a model organism very little is known about the interaction between Drosophila and its microsporidian pathogens. Here we report on the relative
susceptibility of D. melanogaster life-history stages to infection by Tubulinosema
kingi, and on patterns of pathogen proliferation. We find that only larvae can be
infected, and that this susceptibility decreases with larval age. Following infection, the
pathogen shows little subsequent proliferation in larvae, a limited amount in pupae
while it replicates greatly in adults. We present evidence that the host launches a
cellular immune response after infection with the pathogen, although its effectiveness
remains to be demonstrated.
drosophila melanogaster, tubulinosema kingi, diptera, microsporidia, susceptibility, proliferation, immune response, host-pathogen interaction
239-241
Vijendravarma, Roshan K.
42a6e060-5c0b-4f26-9903-61bd9729beda
Godfray, H. Charles J.
69326e74-4061-42de-9cf4-540ed7563a01
Kraaijeveld, Alex R.
4af1791a-15cf-48b9-9fd8-b3a7fb450409
5 March 2008
Vijendravarma, Roshan K.
42a6e060-5c0b-4f26-9903-61bd9729beda
Godfray, H. Charles J.
69326e74-4061-42de-9cf4-540ed7563a01
Kraaijeveld, Alex R.
4af1791a-15cf-48b9-9fd8-b3a7fb450409
Vijendravarma, Roshan K., Godfray, H. Charles J. and Kraaijeveld, Alex R.
(2008)
Infection of Drosophila melanogaster by Tubulinosema kingi: stage-specific susceptibility and within-host proliferation.
Journal of Invertebrate Pathology, 99, .
(doi:10.1016/j.jip.2008.02.014).
Abstract
Despite its importance as a model organism very little is known about the interaction between Drosophila and its microsporidian pathogens. Here we report on the relative
susceptibility of D. melanogaster life-history stages to infection by Tubulinosema
kingi, and on patterns of pathogen proliferation. We find that only larvae can be
infected, and that this susceptibility decreases with larval age. Following infection, the
pathogen shows little subsequent proliferation in larvae, a limited amount in pupae
while it replicates greatly in adults. We present evidence that the host launches a
cellular immune response after infection with the pathogen, although its effectiveness
remains to be demonstrated.
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Submitted date: January 2008
Published date: 5 March 2008
Keywords:
drosophila melanogaster, tubulinosema kingi, diptera, microsporidia, susceptibility, proliferation, immune response, host-pathogen interaction
Identifiers
Local EPrints ID: 50565
URI: http://eprints.soton.ac.uk/id/eprint/50565
ISSN: 0022-2011
PURE UUID: b120b1f5-141e-411e-91e8-0e19b7b59ebe
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Date deposited: 05 Mar 2008
Last modified: 16 Mar 2024 03:48
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Contributors
Author:
Roshan K. Vijendravarma
Author:
H. Charles J. Godfray
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