Pro-epileptic changes in synaptic function can be accompanied by pro-epileptic changes in neuronal excitability
Pro-epileptic changes in synaptic function can be accompanied by pro-epileptic changes in neuronal excitability
Repetitive sensory input, stroboscopic lights or repeated sounds can induce epileptic seizures in susceptible individuals. In order to understand the process we have to consider multiple factors. The output of a set of neurones is determined by the amount of excitatory synaptic input, the degree of positive feedback and their inherent electrical excitability, which can be modified by synaptic inhibition. Recent research has shown that it is possible to separate these phenomena, and that they do not always behave in unison.
epilepsy, Ca2+ channels, sodium channels, NMDA receptors, AMPA receptors, synapses, E/S, LTP, LTD
167-174
Wheal, H.V.
50ba5833-9920-407a-a48a-1fe917534b74
Bernard, C.
97d5a08e-1d4d-4166-b6a8-44b9d2e9dc45
Chad, J.E.
d220e55e-3c13-4d1d-ae9a-1cfae8ccfbe1
Cannon, R.C.
407e49a2-9869-4bad-9f22-86f66f2fde4b
1 April 1998
Wheal, H.V.
50ba5833-9920-407a-a48a-1fe917534b74
Bernard, C.
97d5a08e-1d4d-4166-b6a8-44b9d2e9dc45
Chad, J.E.
d220e55e-3c13-4d1d-ae9a-1cfae8ccfbe1
Cannon, R.C.
407e49a2-9869-4bad-9f22-86f66f2fde4b
Wheal, H.V., Bernard, C., Chad, J.E. and Cannon, R.C.
(1998)
Pro-epileptic changes in synaptic function can be accompanied by pro-epileptic changes in neuronal excitability.
Trends in Neurosciences, 21 (4), .
(doi:10.1016/S0166-2236(97)01182-X).
Abstract
Repetitive sensory input, stroboscopic lights or repeated sounds can induce epileptic seizures in susceptible individuals. In order to understand the process we have to consider multiple factors. The output of a set of neurones is determined by the amount of excitatory synaptic input, the degree of positive feedback and their inherent electrical excitability, which can be modified by synaptic inhibition. Recent research has shown that it is possible to separate these phenomena, and that they do not always behave in unison.
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Published date: 1 April 1998
Keywords:
epilepsy, Ca2+ channels, sodium channels, NMDA receptors, AMPA receptors, synapses, E/S, LTP, LTD
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Local EPrints ID: 56308
URI: http://eprints.soton.ac.uk/id/eprint/56308
PURE UUID: 63dcd104-897e-4bc8-ab6f-a6818fa0fe74
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Date deposited: 22 Aug 2008
Last modified: 16 Mar 2024 02:35
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Author:
H.V. Wheal
Author:
C. Bernard
Author:
R.C. Cannon
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