Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis
Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis
The signalling pathways by which insulin triggers protein synthesis were studied using an antisense strategy to deplete ERK1/ERK2 and rapamycin to inhibit the p70(S6K) pathway. The results indicated that ERK1/ERK2 principally regulated the amount of the protein synthesis machinery available in the cell while the p70S6K pathway contributed to modulating its activation in response to insulin. ERK1/ERK2 also mediated in a small proportion of insulin-stimulated protein synthesis which included the induction of c-fos protein. When c-fos induction was blocked the majority of insulin-stimulated protein synthesis still occurred and thus did not require transcriptional regulation of c-fos or its targets.
insulin, protein synthesis, extracellular signal regulated kinase 1, extracellular signal regulated kinase 2, p70(S6k), antisense
122-126
Sale, Elizabeth M.
bd08d435-24bc-4884-a5fd-cbc97e0835d9
Atkinson, Peter P.G.
854e2408-f39e-4120-9a1b-ea6b2fe3cfc8
Arnott, Caroline H.
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Chad, John E.
d220e55e-3c13-4d1d-ae9a-1cfae8ccfbe1
Sale, Graham J.
81048025-7d8f-4218-969a-bf95ebf50b51
5 March 1999
Sale, Elizabeth M.
bd08d435-24bc-4884-a5fd-cbc97e0835d9
Atkinson, Peter P.G.
854e2408-f39e-4120-9a1b-ea6b2fe3cfc8
Arnott, Caroline H.
60e8f8b6-df7d-4e68-98ea-98b681c8bb66
Chad, John E.
d220e55e-3c13-4d1d-ae9a-1cfae8ccfbe1
Sale, Graham J.
81048025-7d8f-4218-969a-bf95ebf50b51
Sale, Elizabeth M., Atkinson, Peter P.G., Arnott, Caroline H., Chad, John E. and Sale, Graham J.
(1999)
Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis.
FEBS Letters, 446 (1), .
(doi:10.1016/S0014-5793(99)00193-3).
Abstract
The signalling pathways by which insulin triggers protein synthesis were studied using an antisense strategy to deplete ERK1/ERK2 and rapamycin to inhibit the p70(S6K) pathway. The results indicated that ERK1/ERK2 principally regulated the amount of the protein synthesis machinery available in the cell while the p70S6K pathway contributed to modulating its activation in response to insulin. ERK1/ERK2 also mediated in a small proportion of insulin-stimulated protein synthesis which included the induction of c-fos protein. When c-fos induction was blocked the majority of insulin-stimulated protein synthesis still occurred and thus did not require transcriptional regulation of c-fos or its targets.
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Published date: 5 March 1999
Keywords:
insulin, protein synthesis, extracellular signal regulated kinase 1, extracellular signal regulated kinase 2, p70(S6k), antisense
Identifiers
Local EPrints ID: 56751
URI: http://eprints.soton.ac.uk/id/eprint/56751
ISSN: 0014-5793
PURE UUID: c20701d0-2c98-4ab1-b131-0346fd47123e
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Date deposited: 22 Aug 2008
Last modified: 16 Mar 2024 02:35
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Author:
Elizabeth M. Sale
Author:
Peter P.G. Atkinson
Author:
Caroline H. Arnott
Author:
Graham J. Sale
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