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Cushing's syndrome in women with polycystic ovaries and hyperandrogenism

Cushing's syndrome in women with polycystic ovaries and hyperandrogenism
Cushing's syndrome in women with polycystic ovaries and hyperandrogenism
BACKGROUND: A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae. INVESTIGATIONS: Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses. DIAGNOSIS: Cushing's syndrome due to a right adrenocortical adenoma. MANAGEMENT: The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities
cortisol, cushing's syndrome, polycystic ovarian syndrome
1745-8366
778-783
Fegan, P. Gerry
2d2a3783-ee15-47f9-860c-272b325baebc
Sandeman, Derek D.
9a01dfb1-c2b5-46cc-a64c-b76677f4cfd6
Krone, Nils
770eb3c0-dff2-4f01-b679-6746fe4c44bb
Bosman, Deborah
61e88138-4359-4ed9-a742-df71ef4e61bb
Wood, Peter J.
30039979-9541-4a0a-8aef-0dfe53114e02
Stewart, Paul M.
23dbf8c6-344e-4f54-aff6-87ccd98e0c20
Hanley, Neil A.
bf03f7bb-f377-44fb-8344-0bb1ca8b2ef9
Fegan, P. Gerry
2d2a3783-ee15-47f9-860c-272b325baebc
Sandeman, Derek D.
9a01dfb1-c2b5-46cc-a64c-b76677f4cfd6
Krone, Nils
770eb3c0-dff2-4f01-b679-6746fe4c44bb
Bosman, Deborah
61e88138-4359-4ed9-a742-df71ef4e61bb
Wood, Peter J.
30039979-9541-4a0a-8aef-0dfe53114e02
Stewart, Paul M.
23dbf8c6-344e-4f54-aff6-87ccd98e0c20
Hanley, Neil A.
bf03f7bb-f377-44fb-8344-0bb1ca8b2ef9

Fegan, P. Gerry, Sandeman, Derek D., Krone, Nils, Bosman, Deborah, Wood, Peter J., Stewart, Paul M. and Hanley, Neil A. (2007) Cushing's syndrome in women with polycystic ovaries and hyperandrogenism. Nature Clinical Practice Endocrinology & Metabolism, 3 (11), 778-783. (doi:10.1038/ncpendmet0665).

Record type: Article

Abstract

BACKGROUND: A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae. INVESTIGATIONS: Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses. DIAGNOSIS: Cushing's syndrome due to a right adrenocortical adenoma. MANAGEMENT: The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities

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More information

Published date: November 2007
Keywords: cortisol, cushing's syndrome, polycystic ovarian syndrome

Identifiers

Local EPrints ID: 59718
URI: http://eprints.soton.ac.uk/id/eprint/59718
ISSN: 1745-8366
PURE UUID: 648cd5a7-87aa-4db5-a70f-0fd048aa16ea

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Date deposited: 05 Sep 2008
Last modified: 15 Mar 2024 11:17

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Contributors

Author: P. Gerry Fegan
Author: Derek D. Sandeman
Author: Nils Krone
Author: Deborah Bosman
Author: Peter J. Wood
Author: Paul M. Stewart
Author: Neil A. Hanley

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