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Maternal vitamin D status during pregnancy and child outcomes

Maternal vitamin D status during pregnancy and child outcomes
Maternal vitamin D status during pregnancy and child outcomes
Objective:To investigate whether exposure to high maternal concentrations of 25(OH)-vitamin D in pregnancy poses any risk to the child.Design:Prospective study.Setting:Princess Anne Maternity Hospital, Southampton, UK.Subjects:A group of 596 pregnant women were recruited. A total of 466 (78%) children were examined at birth, 440 (74%) at age 9 months and 178 (30%) at age 9 years.Methods:Maternal 25 (OH)-vitamin D concentrations were measured in late pregnancy. Anthropometry of the child was recorded at birth, 9 months and 9 years. At 9 months, atopic eczema was assessed. At 9 years, children had an echocardiogram and a dual energy x-ray absorptiometry scan, blood pressure, arterial compliance and carotid intima-media thickness were measured and intelligence and psychological function assessed.Results:There were no associations between maternal 25(OH)-vitamin D concentrations and the child's body size or measures of the child's intelligence, psychological health or cardiovascular system. Children whose mothers had a 25(OH)-vitamin D concentration in pregnancy >75 nmol/l had an increased risk of eczema on examination at 9 months (OR 3.26, 95% CI 1.15-9.29, P=0.025) and asthma at age 9 years (OR 5.40, 95% CI, 1.09-26.65, P=0.038) compared to children whose mothers had a concentration of <30 nmol/l.Conclusion:Exposure to maternal concentrations of 25(OH)-vitamin D in pregnancy in excess of 75 nmol/l does not appear to influence the child's intelligence, psychological health or cardiovascular system; there could be an increased risk of atopic disorders, but this needs confirmation in other studies.Sponsorship:The study was supported by the Medical Research Council and WellChild (previously known as Children Nationwide).
pregnancy, diet, vitamin d, infant, child
0954-3007
68-77
Gale, C.R.
a569e8fc-5384-402a-b2b2-34843ba9bc05
Robinson, S.M.
d2990871-44a1-48ab-b114-599753849c2b
Harvey, N.C.
2bf1584b-0d61-4f07-ae7e-1f926aac18c9
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Jiang, B.
2ed5b897-3092-4e43-836e-00835559a2fe
Martyn, C.N.
bb7ae7af-c7af-4e79-b719-216733eda771
Godfrey, K.M.
23a43cc5-fc78-4b6e-9e30-16bac46e6d79
Cooper, C.
bf1da25b-a7e3-4938-8b45-6961f8faf735
Princess Anne Hospital Study Group, None
ca1b794c-ac6c-4805-aecc-7b9b4ce48174
Gale, C.R.
a569e8fc-5384-402a-b2b2-34843ba9bc05
Robinson, S.M.
d2990871-44a1-48ab-b114-599753849c2b
Harvey, N.C.
2bf1584b-0d61-4f07-ae7e-1f926aac18c9
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Jiang, B.
2ed5b897-3092-4e43-836e-00835559a2fe
Martyn, C.N.
bb7ae7af-c7af-4e79-b719-216733eda771
Godfrey, K.M.
23a43cc5-fc78-4b6e-9e30-16bac46e6d79
Cooper, C.
bf1da25b-a7e3-4938-8b45-6961f8faf735
Princess Anne Hospital Study Group, None
ca1b794c-ac6c-4805-aecc-7b9b4ce48174

Gale, C.R., Robinson, S.M., Harvey, N.C., Javaid, M.K., Jiang, B., Martyn, C.N., Godfrey, K.M., Cooper, C. and Princess Anne Hospital Study Group, None (2008) Maternal vitamin D status during pregnancy and child outcomes. European Journal of Clinical Nutrition, 62 (1), 68-77. (doi:10.1038/sj.ejcn.1602680).

Record type: Article

Abstract

Objective:To investigate whether exposure to high maternal concentrations of 25(OH)-vitamin D in pregnancy poses any risk to the child.Design:Prospective study.Setting:Princess Anne Maternity Hospital, Southampton, UK.Subjects:A group of 596 pregnant women were recruited. A total of 466 (78%) children were examined at birth, 440 (74%) at age 9 months and 178 (30%) at age 9 years.Methods:Maternal 25 (OH)-vitamin D concentrations were measured in late pregnancy. Anthropometry of the child was recorded at birth, 9 months and 9 years. At 9 months, atopic eczema was assessed. At 9 years, children had an echocardiogram and a dual energy x-ray absorptiometry scan, blood pressure, arterial compliance and carotid intima-media thickness were measured and intelligence and psychological function assessed.Results:There were no associations between maternal 25(OH)-vitamin D concentrations and the child's body size or measures of the child's intelligence, psychological health or cardiovascular system. Children whose mothers had a 25(OH)-vitamin D concentration in pregnancy >75 nmol/l had an increased risk of eczema on examination at 9 months (OR 3.26, 95% CI 1.15-9.29, P=0.025) and asthma at age 9 years (OR 5.40, 95% CI, 1.09-26.65, P=0.038) compared to children whose mothers had a concentration of <30 nmol/l.Conclusion:Exposure to maternal concentrations of 25(OH)-vitamin D in pregnancy in excess of 75 nmol/l does not appear to influence the child's intelligence, psychological health or cardiovascular system; there could be an increased risk of atopic disorders, but this needs confirmation in other studies.Sponsorship:The study was supported by the Medical Research Council and WellChild (previously known as Children Nationwide).

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More information

Published date: January 2008
Keywords: pregnancy, diet, vitamin d, infant, child

Identifiers

Local EPrints ID: 61127
URI: http://eprints.soton.ac.uk/id/eprint/61127
ISSN: 0954-3007
PURE UUID: a82b7997-28ba-4c59-9938-f6f394eca2b1

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Date deposited: 25 Sep 2008
Last modified: 15 Mar 2024 11:24

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Contributors

Author: C.R. Gale
Author: S.M. Robinson
Author: N.C. Harvey
Author: M.K. Javaid
Author: B. Jiang
Author: C.N. Martyn
Author: K.M. Godfrey
Author: C. Cooper
Author: None Princess Anne Hospital Study Group

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